Frau mit drei Autoimmunerkrankungen tritt nach einem „Reset“ des Immunsystems in Remission ein. Chimäre Antigenrezeptor (CAR-) T-Zelltherapie, bei der eine Probe von Immunzellen entnommen, gegen ein bestimmtes Ziel „aufgeladen“ und in den Körper zurückgeführt wird.
https://www.theguardian.com/science/2026/apr/09/autoimmune-diseases-cell-therapy-immune-reset
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>A woman who lived with three life-threatening autoimmune diseases for more than a decade has returned to a near-normal life after a cell therapy reset her wayward immune system.
>The 47-year-old had had nine different treatments, none of which had a lasting impact, before receiving the therapy last year at University Hospital Erlangen in Germany. At the time, she required daily blood transfusions and permanent blood thinning medication to control her illness.
>Within weeks of having the cell therapy, doctors noticed that all three diseases had responded, marking a world first and a striking improvement in the woman’s condition. For the past 14 months she has been in treatment-free remission and largely able to return to normal life.
>Prof Fabian Müller, who led the team, said the speed and depth of the woman’s response was “remarkable” and the therapy had “significantly improved her quality of life”. Clinical trials were needed to learn how durable the therapy was and whether it would be effective for other autoimmune diseases, he said.
>The woman had a rare, life-threatening blood disorder, autoimmune haemolytic anaemia (AIHA), whereby rogue immune defences destroy red blood cells. In flare-ups, patients need immunosuppressant drugs and regular blood transfusions. In the woman’s case, standard treatments were no longer working. “The patient had no treatment options left and would not have left the ward as she needed daily transfusions,” Müller said.
>[Study](https://dx.doi.org/10.1016/j.medj.2026.101075)
CAR-T is basically magic, and nothing is going to change my mind.
This is the real game changer for auto-immune treatment, last time I checked it was a decade away but there are a couple of stories around recovery of different auto immune diseases so it’s looking promising. Fingers crossed.
This could be game changing for Type 1 Diabetes, because a lot of researchers have managed to create insulin-producing cells, but since it’s an auto-immune disease the body just destroys them like it did when the person first developed T1D.
Current research seems focused on encapsulating or hiding these new cells from the immune system. But fixing the immune system this way might be easier and/or more effective
I eagerly await the day this kind of technology can be used to fight allergies.
This is so encouraging. I live with an autoimune condition called psoriasis and it sucks altho not life threatening. It’s been progressing for the last 20 years and the only real therapy right now are immune suppressing drugs which I 100% do not want to take.
The toll this disease has taken on my psyche throughout the years, and many other patients have also expressed, cannot be overstated.
I’m not knocking the immunosuppresent drugs because they’ve been a godsend to many sufferers but for me, the risk is just WAY too high. This therapy tho sounds like they might really be on to something that would lead to a cure.
So „Have you tried turning it off and on again?“ is even an answer to autoimmune disease? This is incredible.
So they extracted a bunch of her T cells, taught them to recognize and attack B cells, put them back in. Then, her T cells killed all of her B cells. Then once her T-cells had all been replaced naturally and wouldn’t attack B cells anymore, her body made new B cells were able to be produced that didn’t have the autoimmune condition?
Am I misunderstanding? It says “The doctors engineered the T-cells to recognise a protein called CD19 found on B-cells and re-infused them into the patient.” Presumably that protein exists on all B-cells and not just faulty ones. They didn’t quite explain how the T-cells wouldn’t just keep attacking her B-cells forever, and that’s the only thing that makes sense.
Damn, I wish mine appeared 10 years later than it did, so it didn’t have time to destroy my body before these new treatments.