Die Studie ergab, dass das Medikament zur Gewichtsreduktion, Tirzepatid, den Alkoholkonsum reduziert und Rückfallverhalten bei Nagetieren verhindert. Diese Ergebnisse deuten darauf hin, dass Medikamente, die auf die Stoffwechselhormone des Körpers abzielen, irgendwann eine Option zur Behandlung von Alkoholkonsumerkrankungen werden könnten.
A popular weight loss drug shows promise for treating alcohol addiction
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>A medication currently used to treat diabetes and obesity may offer a new way to help people struggling with alcohol addiction. A recent [study](https://doi.org/10.1016/j.ebiom.2025.106119) published in eBioMedicine found that the drug tirzepatide reduces alcohol consumption and prevents relapse behaviors in rodents. These results suggest that medications targeting the body’s metabolic hormones could eventually become an option for treating alcohol use conditions.
>Alcohol addiction is a pervasive condition with limited medical treatments. Existing medications only work for some people and are not widely prescribed. This gap in care has prompted researchers to look for alternative approaches that target different systems in the body.
>Recently, researchers have turned their attention to medications that mimic hormones produced in the gastrointestinal tract. These hormones naturally regulate blood sugar levels and the feeling of fullness after eating a meal. Medications like semaglutide mimic one of these hormones, called glucagon-like peptide-1.
>These metabolic drugs have shown early promise in reducing alcohol intake in both animal studies and human trials. Tirzepatide is a newer medication that mimics two different gut hormones at the same time. It targets the glucagon-like peptide-1 receptor alongside another receptor for a hormone called glucose-dependent insulinotropic polypeptide.
>The medication is already approved and widely used for the treatment of diabetes and obesity. Because it activates two biological pathways at once, it often produces stronger metabolic effects than single-hormone drugs. The research team wanted to know if this dual-action drug could also influence the brain circuits that drive alcohol consumption.
It is currently working great for me. Had little desire to drink and even that is easy to ignore. That was not the case prior to starting tirzepatide.
This is interesting. I have found that since giving up alcohol, my tendencies of becoming “hangry” are considerably more pronounced now. I also think sugar consumption plays a huge role of this, and can give me mood hangovers the following day. There is a connection between my blood sugar, metabolism and former alcohol abuse that is really been difficult on me. I feel like there is some Goldilocks zone of chemistry that underlies all of it.
That’s awesome…bet it totally turned around those little alcoholic rodents lives!
I have an anecdotal, total paradoxical (to this idea) story.
Someone I know quite well who started on this drug (Zepbound) about a year ago.
Before starting the medication, she rarely drank but had difficulties with overeating. After, it’s almost the exact reverse – the only saving grace here is that she’s a total lightweight, and 2 drinks have a very pronounced effect on her.
My theory on the situation is that while the drug does reduce cravings for food, or signals ‚full‘ sooner when eating – underlying psychological trauma that may be responsible for the overeating still has a ‚voice‘, and now she’s silencing it with booze, rather than food.
Idk. Just a single observation, thought i’d share.
People trigger hyperglycemia with alcohol to control several braindisorders.
edit: They do this without knowing the reason why. Tirzepatide effects this exact path and therefore disrupts the „need to drink“
edit 2: I’m all for helping people to overcome their addiction. I mean the ‚REASON‘ to drink (for many) is to create hyperglycemia.
I wish it worked that way for me so I’d drink less. 13mg a week and whiskey still hits good. I wonder why this varies.
I was a long time sober person before using GLP-1 medication. I didn’t’t crave drinking much before I started them, so I can’t say there is a difference I can notice.
My S.O. is a moderate drinker. She started Tirzepatide about a year after I started semaglutide.
She hasn’t said anything, but I have noticed a marked decrease in how often she drinks, and when she does how much less she drinks.
For example, Saturday night at home watching movies, she would easily consume a bottle of wine, maybe get into a second. Now, even if she states she’s going to drink a bottle, the next morning there will still be a decent amount left in it. And instead of finishing it the next day, she usually ends up dumping it out.
It’s been a slow progression but interesting to watch.
Worked for me, which I understand is completely anecdotal. But I used to drink wine every day. Now I don’t even think about it.
I did lose the desire to stop on it, however once I stopped the zepbound, and went back on, the drug is not nearly as effective with my reduction in alcohol desire.
Makes sense whenever you overeat it actually turns into alcohol and that’s why we like alcohol so much too. Especially people who over eat
I sure hope they start prescribing it to alcoholics as soon as it’s deemed safe and effective to do so.
Would probably have to start with alcoholics of an above average body weight, people under 160lbs already might accidentally become a bit skeletal.