In einer neuen Studie an Mäusen entdecken Forscher, dass die Injektion von Tirzepatid (Mounjaro) zur Gewichtsabnahme nicht nur den Appetit reduziert, sondern auch braunes Fettgewebe aktiviert, d.
Researchers discover how an anti-obesity drug improves metabolism beyond weight loss
7 Kommentare
Researchers discover how an anti-obesity drug improves metabolism beyond weight loss
To better understand how tirzepatide works, researchers conducted a comprehensive analysis of the drug’s effects on different adipose tissue deposits using an experimental mouse model, as this type of analysis is not feasible in humans. First, they treated obese mice — fed a high-fat diet — with tirzepatide. The results were compared with those of a group of mice that had not received the drug but had consumed the same amount of food. This comparison made it possible to separate the effects of the drug itself from those derived solely from reduced food intake.
The results of the analysis show that tirzepatide activates brown adipose tissue, i.e. it stimulates a type of fat that specializes in ‘burning’ calories from food, unlike white adipose tissue, which mainly stores fat and is the type that accumulates in obesity. “This activation is associated with an increased capacity to burn metabolic energy and with the production of batokines by brown adipose tissue, molecules that are beneficial for metabolism,” says Marion Peyrou.
For those interested, here’s the link to the peer reviewed journal article:
https://www.sciencedirect.com/science/article/pii/S0753332226000892
Mice are intellegent animals.
50 to 100 million mice are tested on each year. They are tortured for profit.
A vile and unnecessary practice.
I just want a pill version.
Now if we could just figure out how to avoid the hair loss that often comes with it!
I love GLP-1s, it’s peak capitalism creating a problem by intentionally engineering food to be hyper palatable and addictive, then giving you an expensive solution. I wouldn’t be shocked if they develop an injectable to build muscle while you sit on the couch watching Netflix.
Also, hasn’t the glp-1 proven to cause significant muscle loss too?
I’ve been on Zepbound for about a year, but got a letter from my insurance company in October saying they weren’t covering it anymore in 2026 for non-diabetes medical issues. They said there are no exceptions. There was even a Q&A section that came with it that pretty much admitted that while using a GLP-1 to lose weight would likely mean less medical issues later in life, its current cost to them doesn’t make it worthwhile to cover.
So instead, once my last supply of zepbound runs out next month, I’m switching to Metformin to hopefully keep some weight off. A diabetes medication. For the diabetes that I don’t have.
I’m also tapering off of an antipsychotic that has worked well for me for 7+ years because of its weight gain effects. All of this because they won’t cover my Zepbound that helped me lose 40 pounds over about 8 months.
But at least my insurance company will keep making ridiculous profits.
If they can get rid of the hair loss, increased risk of osteoporosis, and figure out a way to make it so that the weight you lose doesn’t immediately come back, it will be great. Until then, I’m good