
„Mini-Leber“ wird in einem mutigen neuen Versuch im eigenen Lymphknoten einer Person wachsen. Das Biotechnologieunternehmen LyGenesis hat erstmals einer Person mit Leberversagen Spenderzellen injiziert.
https://www.nature.com/articles/d41586-024-00975-z

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>A person has received an experimental treatment for the first time that, if successful, will lead them to grow an additional, ‘miniature liver’. The procedure, developed by the biotechnology firm LyGenesis, marks the beginning of a clinical trial designed for people whose livers are failing, but who have not received an organ transplant.
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>The approach is unusual: researchers injected healthy liver cells from a donor into a lymph node in the upper abdomen of the person with liver failure. The idea is that in several months, the cells will multiply and take over the lymph node to form a structure that can perform the blood-filtering duties of the person’s failing liver.
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>“It’s a very bold and incredibly innovative idea,” says Valerie Gouon-Evans, a liver-regeneration specialist at Boston University in Massachusetts, who is not involved with the company.
Here is the [company’s announcement](https://www.prnewswire.com/news-releases/lygenesis-announces-first-patient-dosed-in-its-phase-2a-clinical-trial-of-a-first-in-class-regenerative-cell-therapy-for-patients-with-end-stage-liver-disease-302105734.html).
The company has ambitions beyond mini livers: It is testing similar approaches to grow kidney and pancreas cells in the lymph nodes of animals too.