Potentieller Impfstoff und Behandlung gegen Grippe und Coronaviren entwickelt | Team entwickelt zwei Nasensprays – einen Immunaktivator und einen neuen Impfstoff – um die Übertragung des Virus zu verhindern.

From the article: “Using multiple models, the team demonstrated that a single treatment with NanoSTING not only protects against pathogenic strains of SARS-CoV-2 but also prevents transmission of highly transmissible variants like the Omicron variants,” reports Varadarajan. “Delivery of NanoSTING to the nose ensures that the immune system is activated in the nasal compartment and this in turn prevents infection from viruses.”

As the recent COVID19 pandemic illustrated, the development of off-the-shelf treatments that counteract respiratory viruses is a largely unsolved problem with a huge impact on human lives.

“Our results showed that intranasal delivery of NanoSTING, is capable of eliciting beneficial type I and type III interferon responses that are associated with immune protection and antiviral benefit,” reports first author and postdoctoral associate, Ankita Leekha.

The authors further show that NanoSTING can protect against both Tamiflu sensitive and resistant strains of influenza, underscoring its potential as a broad-spectrum therapeutic.

“The ability to activate the innate immune system presents an attractive route to armoring humans against multiple respiratory viruses, viral variants and also minimizing transmission to vulnerable people,” said Leekha. “The advantage of NanoSTING is that only one dose is required unlike the antivirals like Tamiflu that require 10 doses.”