Ein künstlich hergestelltes Probiotikum tötet 43 % aller kolorektalen Tumore bei Mäusen ab: Das künstlich hergestellte E. Coli hat eine dreifache Wirkung: eine direkt im Tumor erzeugte Chemotherapie, ein Immunstimulans und eine lokalisierte Form der Immun-Checkpoint-Blockade.
https://www.sciencealert.com/engineered-probiotic-wipes-out-43-of-colorectal-tumors-in-mice
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Engineered Probiotic Wipes Out 43% of Colorectal Tumors in Mice
Now, scientists have demonstrated a new approach – turning probiotic bacteria into tiny little drug factories that set up shop inside tumors, producing chemotherapy while helping rally the immune system against the cancer at the same time.
When tested in mice, the treatment produced complete regression in three out of seven colorectal tumors.
This time, in addition to the payload for converting 5-FC into 5-FU, the researchers engineered the E. coli to produce two additional compounds: an IL-15 superagonist to goad cancer-fighting immune cells into battle, and a nanobody that blocks PD-L1, releasing one of the brakes tumors use to suppress an immune attack.
The result was a tiny microbe packing a hefty triple-whammy punch – chemotherapy produced directly inside the tumor, an immune stimulant, and a localized form of immune checkpoint blockade.
https://www.science.org/doi/10.1126/scitranslmed.ady2289
This is good news if it turns to be applicable to humans since those types of cancer unfortunately are on the rise.
By the sounds of it this could also mean a minimally invasive treatment method compared to others used today.
Fuck cancer.
That’s is legit nanotechnology! Well, biotechnology, but still.
„Probiotic“ as if that buzzword is doing anything here. It’s genetic engineering. Genetically engineered bacteria are doing this. Fucking „probiotic“.
First glance I read engineered probiotic wipe” and thought huh.. interesting approach.