Ein Nasenspray, das Vesikel enthält, die auf natürliche Weise von Zellen freigesetzt werden, könnte gegen Alzheimer wirken. Es erreicht das Gehirn, wirkt Neuroinflammationen entgegen, schützt die neuronale Funktion und bewahrt das Gedächtnis in einem Mausmodell der Alzheimer-Krankheit und zeigte in vitro positive Ergebnisse in menschlichen Neuronen.
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A nasal spray containing vesicles naturally released by cells may work against Alzheimer’s. This is the promise of a study conducted by researchers at the Università Cattolica, Fondazione Policlinico Universitario A. Gemelli IRCCS, and the E. Menni Research Center of the Fondazione Poliambulanza. The spray is based on extracellular vesicles derived from the amniotic membrane. The study, published in Translational Neurodegeneration (Nature press), demonstrated its ability, in an experimental model of Alzheimer’s: it reaches the brain, counteracts neuroinflammation, protects neuronal function, and preserves memory. The researchers also obtained positive results on human neurons in vitro.
Researchers have demonstrated that these nanovesicles, administered intranasally to an animal model that mimics the clinical picture of Alzheimer’s disease, reach the hippocampus, a brain region crucial for memory and particularly vulnerable in Alzheimer’s disease. There, they enter into both neurons and microglia, cells that play an important surveillance and defense role in the brain. The beneficial effects of this treatment affect various aspects of the disease, from modulating neuroinflammation to protecting neuronal function and, in particular, synapses, the connections that ensure information transmission in neural circuits, resulting in a significant improvement in cognitive abilities. The extracellular vesicles are able to both prevent the onset of memory deficits and counteract cognitive decline once it has already occurred.
https://link.springer.com/article/10.1186/s40035-026-00581-1
Really sucks seeing things like this while my mom is dealing with mid stage alzhimers. I know none of them will be ready in time.
This tech is exciting, not just for the treatment of Alzheimer’s. This artificial EV tech might be the first steps to one day developing a preventative against flu and covid or as a vehicle for crossing the blood brain barrier and addressing all kinds of brain related issues. I’m imagining something like this for delivering lithium, stimulants, or peptides, etc… exciting stuff!