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    DNA-Mutationen in Neuronen und Herzzellen begrenzen laut Studie die mögliche Lebenserwartung des Menschen auf 156 Jahre

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    1. multihome-gym on

      Submission statement:

      A recent study conducted in Russia suggests that despite recent advances in aging research, DNA mutations in brain and heart cells might limit possible human lifespan to a maximum of 156 years.

      The research team estimated human survival rates under the hypothetical scenario where aging causes like telomere shortening and protein damage are eliminated, leaving only somatic mutations. The analysis revealed that neurons and heart muscle cells were the primary barriers to longevity beyond age 156. These cells rarely divide or regenerate, making it difficult to replace damaged ones. As mutations cause individual cells to die, brain and heart functions could decline irreversibly over time.

      In contrast, organs with high regenerative capacity, like the liver, were more resilient to mutations. Liver cells can be continuously replaced even after damage or death.

      However, the study has limitations. It is a theoretical estimate based on mutation rates, cell counts, and organ dysfunction criteria in human tissues, not clinical trial data.

    2. spottyPotty on

      Didn’t telomere shortening and the finite number of cell generations (7 IIRC) already limit that to 120 years?

      Edit:

      > 
      under the hypothetical scenario where aging causes like telomere shortening

      Ok

      Edit 2:
      Quite a significant hypothetical to omit from the title

      Edit 3: According to the [Hayflick limit](https://en.wikipedia.org/wiki/Hayflick_limit):
      The typical normal human fetal cell will divide between 50 and 70 times before experiencing senescence. 

    3. Ragnar5575 on

      I don’t know why anyone wants to live longer than even 90 years. I’ve seen first hand through medical work how badly the body begins to deteriorate. No thanks. I’ll die at 80 in my sleep ( hopefully ) and be perfectly happy with that.

    4. OneOnOne6211 on

      I mean, what does the really mean though? It seems to me that this is just another potential obstacle to overcome for life extension. Which, it is by far not the only one. I feel like this one is no more special. Now, if we solve all the other problems of aging and this particular one proves particularly hard to solve, maybe. But until then, we might solve this problem, before we solve the telomere one. Or any other number of problems. Or we may solve it at the same time. Not saying the study has no value, just saying that framing it as limiting „possible human lifespan to 156 years“ is kind of misleading. Because it makes it sound like no matter what science comes along, we can never live passed that. When the reality is that it’s just another in a line of many obstacles that have to be overcome to live longer.

    8. xxxx69420xx on

      imagine evolving this far and just putting up a wall like were humans we stop here, no more ascending up through time and space we decided this is the best race in space. kind of took of there at the end

    9. guaztronaut on

      I wanted to be 150 when we lived in the original timeline. Fuck this one. I don’t even want to make 50.

    11. Uncabled_Music on

      russia, the place you are lucky to retire alive (many don’t make it, and it’s currently at age 64).

    12. _Nightdude_ on

      so half the time you read stuff saying „Millenials to be the first generation that doesn’t have to die“

      and this.

    13. knightmechaenjo on

      MOR YEARS PLS!

      I am not at all comfortable with knowing I have a set limit!

      I want to be immortal!

    15. Vectorman1989 on

      156 is great and all, but I think other factors would probably severely limit our quality of life long before that.

    17. luluhouse7 on

      I wish we would stop spending so much time and money on life extension instead of improving QOL as we age. Who wants to live forever unable to move or think or in copious amounts of pain? The limiting factor isn’t actually maximum life span right now. People usually die well before their potential from illnesses like cancer or dementia or strokes/heart attacks or even from depression and loneliness. IMO this is putting the cart before the horse.

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