Regelmäßiges, langes Schlafen pro Nacht wird mit einem höheren Spiegel eines Alzheimer-Proteins im Blut in Verbindung gebracht, auch wenn andere Gesundheitsfaktoren berücksichtigt werden
Regelmäßiges, langes Schlafen pro Nacht wird mit einem höheren Spiegel eines Alzheimer-Proteins im Blut in Verbindung gebracht, auch wenn andere Gesundheitsfaktoren berücksichtigt werden
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Regularly sleeping long hours each night is associated with higher levels of an Alzheimer’s-related protein in the blood, even accounting for other health factors, suggests a new study from UT Health San Antonio, the academic health center of The University of Texas at San Antonio.
Modeling across a sample of 2,410 study participants found a link between sleep duration and phosphorylated tau 181, or p-tau181, a modified form of tau protein that is a hallmark of Alzheimer’s disease, and is now detectable in blood.
Regular sleep durations beginning at eight-and-a-half to nine hours per night were associated with higher p-tau181 levels, increasing most sharply beyond 10 hours, suggesting that long sleep might reflect early neurodegenerative processes.
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71499
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Key discussion paragraphs:
> A critical consideration is that self-reported long sleep duration may reflect poor sleep quality rather than (or in addition to) extended time spent asleep. Self-reported sleep duration instruments can capture time in bed, which is the total time spent lying down on a bed rather than actual sleep time achieved. Thus, individuals with fragmented sleep, frequent awakenings, or reduced slow-wave sleep often compensate by spending more time in bed, inflating self-reported duration while experiencing less restorative sleep.39, 40 Slow-wave sleep is the primary window for glymphatic clearance of Aβ and tau,41 meaning that > 8.5 hours of fragmented sleep may provide less clearance than 7 hours of consolidated sleep. However, mechanisms underlying long sleep associations likely differ from those of short sleep. Notably, we observed no associations between short sleep and AD biomarkers despite glymphatic theory predictions, possibly reflecting heterogeneity among short sleepers. Individuals with voluntary or genetically determined short sleep may differ biologically from those with insomnia-related short sleep driven by hyperarousal,42 with the former potentially maintaining adequate sleep quality and consolidation while the latter may experience more fragmented, less restorative sleep with greater neurobiological consequences, or compensatory napping behaviors not captured by our sleep measure.
> Concerning long sleep, tau accumulation in sleep-regulatory regions, including the locus coeruleus, basal forebrain, and brainstem nuclei at Braak stage 0 and I (before cortical involvement) could disrupt wake-promoting circuits,43 thus triggering compensatory increases in sleep duration before cognitive symptoms emerge. This interpretation is consistent with evidence showing that long sleep duration associates with tau burden in sleep-regulatory regions and can predict faster progression to MCI or dementia.44 Objective sleep studies measuring sleep stages alongside AD biomarkers are needed to disentangle these possibilities.
Basically the need or drive to sleep for so long is likely to reflect an underlying issue (not necessarily that people are harming their health by *choosing* to sleep longer).
Who has time to sleep 10 hours on a consistent basis? That’s nearly half the day.
So there’s a ‚Goldilock’s Zone‘ for sleep too just like there is for so much else to do with the body.
Makes sense.
Would it being detectable in blood suggest that it’s being cleared from the brain?
Could this study be mistaking causation for correlation? As in, maybe people who have chronic health issues and inflammation are more likely to be disabled and sleep long hours and the health issues increase the alzheimers risk. Maybe the long sleep is just a symptom of the underlying cause.
Does it need to be continuous? We are usually woken up around midnight by the dogs. Not to mention normal wake up to turn over, go potty, etc…
Sleep too much, dimentia.
Sleep too little, also dimentia.
Is sleep causing dimentia?!
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In the blood? Isn’t that where I want it, since that means it got flushed out of my brain? Isn’t that what quality amounts of REM sleep does: flush the amyloid proteins out of the brain?
But why are those people sleeping more hours? Is that taken into consideration?
Sleeping that long 100% has to have another underlying issue causing this. I can’t imagine sleep itself is the cause.
Fu, imma keep my druidic ways!
Some people sleep more because they just don’t want to be awake and deal with their depression, etc. I wonder if they could set up a study to differentiate between these 2 groups. Something tells me these 2 groups would have different results.
Maybe it’s an early symptom and not a cause?
Good thing I only sleep regular, 60 minute hours.
So what’s the solution to fix it?
Funny there was also a post recently saying lack of sleep was a cause.
The solution is simple – don’t sleep.
Yeah and regularly sleeping less hours each night makes you miserable all sorts of other health problems. I’ll take the long hours and it’s health benefits
It seems like such a weird take though, most animals I see and know do take smaller naps throughout the day, I’d like to think humans are/were also the same until full work days became the norm that make it much harder to take a quick nap one way or the other..
It just confuses me how sleeping a lot would increase your risk of Alzheimer’s that much, unless we’re talking 10-16 hours of sleep.. While sleeping too little also seems to increase the risk the same way?
As someone who sleeps 16+ hours on non-work nights, and 12+ hours on work nights, I’ll report back on my Alzheimer’s status when it happens…if I remember.
Can’t fuckin win in this life.
So not sleeping enough: Alzheimers. Naps: Alzheimers. Sleeping too much: Alzheimers.
How much sleep is enough vs too much? Who knows, check back once a week to see what the latest paper says.
Funny, I just read that deep sleep is what prevents Alzheimer’s.