Helminthen unterdrücken nicht nur entzündliche Th17-Zellen – sie programmieren sie auch in Zellen mit einem regulatorischen, Treg-ähnlichen Phänotyp um, wie eine neue Studie an Mäusen zeigt. Zellen, die einmal IL-17 exprimierten, wechseln zur Produktion von IL-10, gewinnen Foxp3-Expression und reduzieren Entzündungen in einem Mausmodell für Morbus Crohn-ähnliche Kolitis
https://pmc.ncbi.nlm.nih.gov/articles/PMC13161039/
5 Kommentare
Picture gremlins. You’ve got mean gremlins that break everything (pathogenic Th17 cells) and calm gremlins that repair the damage (Tregs). We already knew helminth exposure shrinks the mean gremlin population and grows the calm one.
What we didn’t know: there’s also a magic wand that turns certain mean gremlins into calm ones, on the spot — the same individuals, literally switching sides.
That’s great! Everyone knows hat humans and mice are CLOSELY related.
We can bring out the champagne.
I have Crohn’s. I also refuse your worms.
Worms you can pick up from pond water… $0, fancy cleaned worms from pharma… $20,000.
This work in interleukin chains is giving me hope. Without inflectra I’ll die. With it I can function with about 80% of my health. But the cognitive load of the 20% or so of lost recovery has been a drag and locked me into a burnout.