Neue Studie stellt Trocken-mRNA-Impfstoff-Mikronadelpflaster vor, die Hunderte winziger Spitzen verwenden, um den Impfstoff als Alternative zu herkömmlichen Injektionen in die Haut zu verabreichen. Ein Design, das dazu beitragen könnte, künftige mRNA-Impfstoffe einfacher zu lagern und zu verteilen und den Bedarf an Kühlkettenlogistik zu reduzieren.

New study advances dry mRNA vaccine patch design
New research could help make future mRNA vaccines easier to store and distribute.

The study, involving RMIT University, the Massachusetts Institute of Technology and Harvard Medical School, identified conditions that help protect the particles that carry mRNA in dry vaccine patches, offering practical guidance for future patch design.

Published in *Advanced Functional Materials*, the study examines what happens to the fragile particles used to carry mRNA when they are dried into the dissolvable material used in microneedle patches. The patches use hundreds of tiny tips to deliver vaccine into the skin as an alternative to traditional injections.

Reducing the need for cold-chain logistics could help remove one barrier to vaccine delivery, particularly in lower-resource settings. In 2024, 14.3 million children globally received no vaccines at all, according to the World Health Organization and UNICEF.

https://advanced.onlinelibrary.wiley.com/doi/10.1002/adfm.75716