Eine Studie in Tiermodellen ergab, dass eine hohe Fruktoseaufnahme durch gesüßte Lebensmittel und Getränke bei schwangeren Frauen mit einer erhöhten Anfälligkeit für Diabetes und Herz-Kreislauf-Erkrankungen sowie neurologischen und kognitiven Beeinträchtigungen bei den Nachkommen in Verbindung gebracht wird

> the performance of adult rats in learning and memory tests was impaired when the rats had been exposed to high fructose in before birth by feeding their mothers with high fructose corn syrup. Furthermore, neurogenesis, which is the generation of new neurons from neural stem cells (NSCs), in distinct regions of the brain involved in learning and cognition was reduced in those rats. Further, Yamada’s group discovered distinct changes in NSCs after high fructose exposure, which included reduced cell division and impaired generation of new neurons, and altered gene expression. To explain why prenatal high fructose exposure can have such long-lasting effects on NSCs, the researchers profiled the so-called epigenetic changes, which are chemical imprints on the DNA controlling gene activity. Strikingly, prenatal high fructose exposure introduced distinct epigenetic changes in fetal NSCs which persisted into adulthood and which deregulated the activity of genes important for adult neurogenesis. Restoring normal expression of those genes improved the function of high fructose-exposed NSCs

> This research illustrates how early-life exposure to an adverse environment, e.g. an imbalanced maternal nutrition, can have long-lasting effects on brain development and function by changing the epigenetic regulation of gene activity in NSCs. Importantly, although epidemiological studies in human populations show similar correlations, further studies will be required to test if human NSCs are affected by high fructose and other environmental stressors in similar ways

[Neural stem cells as potential mediators of prenatal dietary stress through epigenetic mechanisms: Stem Cell Reports](https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(26)00207-9)

Yikes! As a 36 week pregnant person, I have been drinking so many sweetened beverages like lemonade, Gatorade, orange juice etc. cut with half water in order to get my fluid intake up in this heat. I’ve struggled with low amniotic fluid. This is concerning to read…