Forscher haben herausgefunden, dass gesunde, aber bewegungsarme Personen einen erheblichen, koordinierten Rückgang der Muskel-Mitochondrienfunktion aufweisen, der der Entwicklung schwerer Krankheiten wie Krebs, Diabetes und Alzheimer vorausgehen kann.
https://news.cuanschutz.edu/news-stories/healthy-but-sedentary-individuals-show-early-decline-in-cellular-energy-production?utm_campaign=Mitochondria_Release&utm_source=Reddit&utm_medium=social
12 Kommentare
Yes, lifting weights protects you from mental decline. The irony of it is we can all remember the „big dumb weightlifter/jock“ stereotype that was prominent in past generations.
Another reason to aim for 150 minutes of weekly exercise:
„Mitochondrial function is the center of metabolic health,” said the study’s senior author Iñigo San Millan, adjoint assistant professor in the Division of Endocrinology, Metabolism and Diabetes at CU Anschutz. “If you are 40, healthy, and sedentary, it is likely that you already have something going on inside your cells that will likely come back to haunt you in 10 or 15 years.”
The study specifically noted that mitochondria, which process energy within cells, showed a significantly decreased capacity to burn both sugar and fat in healthy individuals who get less than the recommended 150 minutes of exercise a week. Researchers also found that sedentary muscle contained about half as much of a key protein needed to convert sugar into usable energy.
Jokes on you, i already have diabetes and had cancer.
This is the problem with classifying healthy as absence of disease. If you are sedentary you are very unlikely to actually be robustly healthy and it’s only a matter of time before reality catches up in the form of measurable disease.
Welp, Long COVID messed up my mitochondria and gave me Post Exercise Malaise (PEM). So add this to the list of reasons our mortality rates are climbing.
I have exercised religiously since about 12 years old. I won the regional Golden Gloves boxing tournament a few years straight in my early twenties. I continued exercising and staying fit into my early 40’s, jumping rope every morning for at least an hour, often without rest. At 42 I tore my bicep sparring and had it reattached. The attachment failed twice before the third surgery when it stayed attached and healed. During this time I stopped exercising for about a year and a half. Found out about a year in without exercise that I had cancer. Oddly enough, I’m typing this on a chemo drip at a clinic
I essentially spent 5 years in bed in my 20s because I was ill
Am I fucked?
People that are sedentary are not healthy. Not sick ≠ healthy.
I’d be interested in the interaction here with metformin, since that acts on mitochondria.
The research shows a cross-sectional difference in mitochondrial function between a small number of men selected *because* they are active or sedentary. Undoubtedly this precedes the development of these diseases – by *definition*, they excluded people who had diabetes and heart disease!
Any notion that this impaired mitochondrial function is causal on that disease pathway is conjecture from this data, and any downstream association is highly confounded. It may well be equivalent to suggesting with the same dataset that low VO2 max or watching more TV causes cancer.
Of course the benefits of exercise have been shown in so many ways, but seems to me these particular results should be viewed with scrutiny given a sample size of only nine sedentary and 10 active participants.
Peloton Power Zone Endurance rides focusing on zones 2/3 are a great way to achieve the 150 min the AHA recommends. I have done 250 miles a month every month so far in 2026; it’s great way to destress after working from home!