GLP-1-Medikamente zur Gewichtsreduktion können auch bei Hauterkrankungen wie Psoriasis oder Ekzemen (atopischer Dermatitis) helfen. GLP-1-Rezeptoren kommen nicht nur in der Bauchspeicheldrüse und im Magen-Darm-Trakt vor, sondern auch auf Immunzellen. Diese Medikamente können die Entwicklung einer chronischen Entzündung direkt beeinflussen.
Can diabetes and obesity drugs also help the skin? The potential of GLP-1 agonists in dermatology
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GLP-1 receptor agonists are currently among the most widely discussed classes of drugs worldwide. They have gained popularity for their effectiveness in treating type 2 diabetes and obesity, but increasing evidence suggests their effects may be much broader. Recent studies indicate that they may also influence inflammatory processes responsible for the development of many skin diseases.
In a scientific review published in Pharmaceutics, researchers summarized current knowledge regarding the potential use of GLP-1 receptor agonists in dermatology. Their possible applications in psoriasis, atopic dermatitis, hidradenitis suppurativa, and chronic wounds, among others, were analyzed.
From incidental observations to a new research direction
The history of dermatologists’ interest in GLP-1 drugs began with observations of patients treated for diabetes and obesity. Physicians noticed that, in some patients, improvements in metabolic parameters were accompanied by a reduction in the severity of skin lesions.
*Initially, these were isolated clinical observations concerning patients with psoriasis. Over time, researchers began to wonder whether specific biological mechanisms might be responsible for this effect, rather than merely an improvement in overall health associated with weight loss, –* explains Dr. Małgorzata Ponikowska from the University Center of General and Oncological Dermatology at Wroclaw Medical University.
A breakthrough came with the discovery that GLP-1 receptors are found not only in the pancreas and gastrointestinal tract, but also on immune cells. This means that drugs from this group may directly affect mechanisms responsible for the development of chronic inflammation.
This material is based on the article:
GLP-1 Receptor Agonists in Chronic Inflammatory Skin Diseases: Immunometabolic Mechanisms and Translational Perspectives
[https://doi.org/10.3390/pharmaceutics18050605](https://doi.org/10.3390/pharmaceutics18050605)
How frequently would this medicine need to be taken?
Maybe not the place for an anecdote but this has been one of the best “side effects” of my shot and/or weight loss.
I can tell you that I tried Mounjaro and I have HS. The very first dose caused my skin to calm in a way it hasn’t done in years, but only the first dose caused it. Activity returned to normal after the first month.
I’ve since discontinued due to high costs. My skin has gone absolutely crazy. It’s active in all the usual places as well as extremely pain occurrences in brand new areas. I haven’t had new areas in decades…
GLP1 has brought my inflammation down soo much. Within eight weeks my bracelets were looser, I could wear my nice Swiss watch again, my rings fit, my face slimmed, my joints in my hands were less red. It was shocking!
Retatrutide completely replaces my wife’s prescription eczema medication. If we go on vacation and she doesn’t take it for a week or so her hands start to flare up.
Kind of shocked it helped out my eczema. It’s not fully stopped but greatly reduced.
I have been suggesting to me and my wife that we stay off this stuff bc it’s so new, we don’t really know what the side or long term affects could be. But everyday something else comes out saying it also reduces risk of cancer, psoriasis, etc etc etc…kind of feeling like a dummy for not taking these magic pills.
I have inverse psoriasis and my dermatologist said it’s just something I have to live with. It mostly affected my finger nails. The beds under the nails would grow in 3 days what normally takes 30, resulting in lifted nails. It’s almost completely gone and it is such a relief. Tirzepatide in this case.
If they are so effective when what are the implications of the drug for those WITHOUT these conditions? The drug doesn’t know who has psoriasis and who doesn’t. Awesome if it helps these things but for those without an overactive immune disorder what is the constant stimulation of the immune cells glp-1 receptors doing?
There is no such thing as a free lunch. Every action has downstream effects. The cult like following these drugs are getting fueled by tens of billions in advertising budgets is scary.
It doesn’t improve my psoriasis though :/
Life changingly improved my eczema
Been on Zepbound for a few months now, apart from weight loss/appetite suppression & getting full faster, inflammation everywhere has gone down and my energy is far higher. To the point I’m sleeping less because I simply wake up rested faster.
The cost of them needs to come down sharp, because these benefits and the others reported by users should be available to everyone. Thankfully my insurance covers it, but for a lot of others it doesn’t.
Maybe it’s just that you are eating less of the poison the rest of us are getting.
Honestly, until they make a over the counter variant most people will sadly not have access to many of these drugs based on how much insurance is.
GLP1 receptors are actually all over the body- in the GI system, renal system, musculoskeletal system, CNS… I think we’re gonna see a lot of „unexpected“ benefits over the next several years.
Fascinating how every positive comment in this thread about someone’s experience with these drugs is from a private account.
There is no doubt that GLP-1 agonists are beneficial to many persons who suffer from weight and/or metabolic conditions that create less-than-ideal conditions for optimal health; they have been a life-saver for many people.
That said, there are well-known side effects of these drugs that one must take into consideration.
At present, many persons who are not in dire straits relative to metabolic-related diseases, or who are on the margins, have tried to use these drugs to tweak their metabolisms.
GLP-1 agonists are spectacular in their short-term results for may, but for the rest of us (many on the margin) [there are research-based alternatives that can trigger GLP-1.](https://health.osu.edu/wellness/exercise-and-nutrition/activiating-glp-1-naturally)
It’s important to be aware of these alternatives because GLP-1 drugs are being demanded and prescribed to many persons who might do better to make long-term lifestyle changes. Always consult with your physician.
I wonder how many of those who have been/ are critical of vaccines are now happily using GLP.
I’ve definitely noticed some improvements with my keratosis pilaris on my arms
I have an immune disorder called Hereditary alpha tryptasemia syndrome, and there are a lot of people in my groups talking about how low doses calmed their reactions. It really does seem to help with inflammation… On the other hand an unlucky few say it triggered their mast cell disorder so I guess everyone is different. I’m only a couple pounds overweight, but I’m considering testing it out if I’m still struggling with the heat and sun next summer
All I know is I suffered from chronic diverticulitis flairs and was considering surgery to remove part of my diseased bowl with the risk of a permanent colostomy at 44yo.
I have been flair free for 1.5 years since I have been on GLP-1s, quadrupling my longest stint since my first Diverticulitis attack.
Seems like every month there’s a new study about unintended benefits of these medicines. I’ve recently seen articles that are also saying that GLP-1s can even reduce aggressive/violent behavior.
So the question is, is this due to suppression of appetite and thus not eating foods that would otherwise cause inflammation, or is it something else about how these drugs work in the human body that separately reduces inflammation?
I hope GLP-1s are the cure to all the COVID induced autoimmune disorders and we start ourselves in a pharmaceutical House That Jack Built situation.