Wirksamkeit der Vitamin-D-Supplementierung bei Patienten mit diagnostizierter Depression: eine Dosis-Wirkungs-Metaanalyse randomisierter kontrollierter Studien
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1772451/full
Wirksamkeit der Vitamin-D-Supplementierung bei Patienten mit diagnostizierter Depression: eine Dosis-Wirkungs-Metaanalyse randomisierter kontrollierter Studien
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1772451/full
13 Kommentare
Worked for me anecdotally. I take 2000 iu and tested by doc originally for it
Hasn’t this been studied time and time again? Why the mixed results? This seems to confidently prove an improvement over placebo
10,000 IU daily for me. Doctor’s „prescription.“
„Results: The outcomes were reported in 15 studies encompassing data from 962 participants. Vitamin D supplementation demonstrated a significant improvement in depressive symptoms compared to the placebo group (SMD: −0.98; 95% CI − 1.28 to −0.68; p < 0.001).“
This effect is about 3.5x higher than the effect found in meta analyses of effects for modern antidepressants!
Though those of course include far more studies and participants and thus have narrower confidence intervals. Still, even the bottom of the CI here is more than twice as large as the point estimate for AD trials.
They do not find this to be the result of publication bias, and it remains unchanged when studies at high risk of bias are removed.
They do find it is substantially larger when depression is measured by patient rating scales vs clinician rating scales, the latter of which are typically used in AD trials. However even using clinician rating scales, the effect here is about twice as large than that for ADs. (The only meta-analysis for ADs using patient rating scales I can find didn’t find any effect of ADs at all, though it was restricted to youth).
The effect seems to be especially strong in female participants and patients with obesity.
Isn’t vitamin D testing and treatment the standard of care for depression? It has been as long as I’ve been practicing
I always wondered if this is why Americans are ( at least until recently) stereotypically more cheerful than Europeans. It really seems like the eu should put vitamin d in their milk, given the reduce relative sunshine.
Touch grass is good mkay.
I feel like I’m crazy? Do the secondary outcomes as reported in the text and abstract not directly contradict what is shown in table 2
If so how tf is this published
Their dose-response curve doesn’t come anywhere near their data points….
Edit- and heterogeneity was extraordinarily high. They’re drawing a conclusion from data that are all over the place
So does this mean I should actually take my vitamin D or just feel guilty about not taking it?
Novice here. Is it correct that in order for vitamin D to metabolize you need to be in the sun? If so, isn’t the ultimate answer to depression is just to get some sun?
Quite a few of the meta-analysed studies are on groups of people with vitamin d deficiency. While theoretically okay, this doesn’t seem to be mentioned explicitly anywhere and definitely impacts the interpretation. Also, where a study has two treatment groups, it looks like they have simply used the comparison to the same control group twice creating non-indepedence between the results. Not great
I hope they test D levels of the patients they supplement at such high doses.
A target range would be more appropriate especially with the down side of elevated D levels