Einmal täglich einzunehmende Pille wirksam bei der Behandlung von Schlafapnoe ohne CPAP. In klinischen Studien verringerten sich die Atemaussetzer bei Personen, die die Pille einnahmen, um etwa 44 %, verglichen mit fast 18 % bei Personen, die ein Placebo einnahmen. Fast jeder Fünfte, der die Pille einnahm, erreichte eine vollständige Linderung seiner Schlafapnoe
https://site.thoracic.org/press-releases/once-nightly-pill-treats-causes-of-airway-collapse-to-control-osa
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A once-nightly oral pill helped control obstructive sleep apnea in a large, phase 3 clinical trial presented at the 2026 ATS International Conference. The drug, called AD109, is the first therapy to treat OSA by addressing its underlying mechanisms and targeting the neuromuscular causes of airway collapse. “Aroxybutynin and Atomoxetine (AD109) for Obstructive Sleep Apnea: A Randomized Phase 3 Trial” will be published in the American Journal of Respiratory and Critical Care Medicine.
The trial, called SynAIRgy, showed that patients who took AD109 had fewer breathing interruptions during sleep, less oxygen deprivation, and improved blood oxygen levels overall. More than 40 percent of patients saw their OSA disease severity category improve, and 18 percent achieved complete disease control.
https://academic.oup.com/ajrccm/advance-article/doi/10.1093/ajrccm/aamag215/8680221?login=false
Wow, that sounds amazing. Though I’m struggling to understand how medication (vs surgery) could fix it.
Currently just starting with a CPAP machine, and struggling with it.
How was there an 18% placebo affect for people when they were unconscious (asleep)? That’s amazing
I remember checking in with my doctor after my sleep study. He told me something very sobering. ‚Yes, a good night’s sleep is important… but the silent killer here is the lack of oxygen for your brain. Years of O2 depletion is a direct path to early stroke and death.‘
The masks aren’t fun, but it is worth it.
Also, as others have said, don’t settle on your setup. It is worth trying any and all masks, pillows, headsets etc.
Placebo effect was huge.
I can’t help but notice that one of the common side effects of this treatment is insomnia, which I feel runs counter to the drugs intended purpose
Interesting. This could be lifesaving for many people when paired with CPAP therapy.
Will have to read more into their population characteristics though; not sure how effective this would be in the large necked obese patient. Relaxing the muscles of the neck/airway in that population just sounds like a recipe for a worse obstruction i.e physics.
This is pretty shocking. I very much hope it pans out. I believe i I read that untreated severe sleep apnea has life expectancy around ten years at diagnosis.
Not so surprising. I began taking Guanfacine five months ago for adhd as an addon to my Concerta.
In the first month my snoring recorded on my Samsung galaxy watch went from 200 plus minutes a night average to between 15 to 30 mins a night.
Different mechanism of action where guanfacine is an Alpha2 agonist, but still. Seems to be linked to the drug effects on sympathetic tone.
It was a completely unexpected side benefit but i’ll take it.
A few things to bear in mind.
1) These are all people who refused or could not tolerate CPAP.
2) The outcome here is breathing events per hour that led to an oxygen desaturation of >=4%. That reduction looks pretty real, although reporting geometric mean makes the reductions sound bigger than they are: median baseline is 19.6 events/hour and the modelled reduction was -4 events/hr.
3) But, they changed the endpoint from a responder analysis towards the end of the trial…? See change history [here](https://clinicaltrials.gov/study/NCT05813275?tab=history&a=22&b=23#version-content-panel), and [this abstract from May 2025 (two months after trial finished enrolment) states](https://academic.oup.com/sleep/article/48/Supplement_1/A339/8134797?login=false) „The primary efficacy endpoint is the proportion of participants with ≥50% reduction in AHI4 at six months.“ – there might be an innocent explanation, but this is very poor conduct, and this endpoint was NOT significant in the final analysis (p=0.182).
4) ~21% of people stopped taking the drug due to side effects before week 26, the most common reason being… insomnia.
5) Relatedly, there was no meaningful difference in patient-reported fatigue scores, which was the key secondary endpoint (the trial was partly powered on it).
So – a mixed bag.
Ho tf can a placebo work on 18% of people SLEEPING
As someone with severe OSA who cannot do CPAP (triggers intense claustrophobia and panic attacks) but cannot afford Aspire or similar modern treatments this sounds like a dream come true. I hope it makes it to market sometime in my lifetime so that I can finally get decent sleep without needing sleeping pills.
This is incredible. I was diagnosed with Sleep Apnea in my 20s, and felt so much shame that I couldn’t be the spontaneous, effortless, chill 20something that all my friends were. Dating was a NIGHTMARE. A cpap is NOT sexy.
Furthermore, I have pretty major sensory issues, and a CPAP made it much harder for me to fall asleep.
Fortunately, weight loss helped the apnea and my 30s were much easier, but I know it’ll be back as I get older, and to have a pill instead of head gear is an enormous quality of life improvement.
I’ve tried every kind of CPAP mask from the full mouth and nose, just nose, the nose buds and I could not stick with it. It’d be uncomfortable and my sleep would be worse. I’ve lost weight and that has helped but if something like this could get someone like me across the finish line this would be life changing.
Plus Atomoxitine can be a great appetite suppressor, not sure what dissing is going on here though. It is prescribed for ADHD so probably affects going to sleep
I literally came across this article yesterday when I was doing some research on how effective Strattera is for ADHD.
My takeaway is the I should try the placebo. Bit not know It.
Now we wait for the price to drop.. I predict an arm and a leg to stay alive
Unfortunately CPAP didn’t work for me after multiple tries with multiple masks for multiple years. Positional therapy, humidifier, and vertical tape on mouth is what is keeping me alive.
Please PLEASE don’t let this be a dud. I suffer from sleep apnea and my days are a constant struggle just to stay awake.
I have sleep apnea but cannot really tolerate a CPAP due to chronic sinus issues. This would be amazing for me. (I am going to try and get one of the dental apparatuses)
Cures not pills please.
Just tell me what stock do I buy :p
I’ve been a CPAP user for about 7 years and I’m married to it. With weight loss I’m down to 5 interruptions or less an hour.
This could be a game changer for many but I am happy with my current treatment
Okay, so what I haven’t seen mentioned yet in this thread, are snore braces for at least mild obstructive sleep apnea. I got diagnosed with it last year, but it wasn’t severe enough to warrant a sleep lab visit and a cpap. So I ordered these braces that push my lower jaw forwards by like 5-10mm and it has basically cured my snoring and sleep apnea. The difference when waking up and the overall sleep quality is nuts.
After 20 years of using one I don’t know if I could go to sleep without it. ars
18% reduction from placebo?
And when you want to stop this pill, it will probably takes you 6 months tapering off and terrible withdrawal symptoms. Like every oher wonder pill.
But they won’t tell you.