Ein neuer Ansatz zur Krebsimpfung führt mithilfe von mRNA-Impfstoffen zu stärkeren T-Zellen. In Studien an Mäusen hat der mRNA-Krebsimpfstoff die meisten Tumoren vollständig ausgerottet, darunter Blasenkrebs, Dickdarmkarzinom, Melanom und metastasierten Lungenkrebs.

A new approach to cancer vaccination yields more powerful T cells

MIT engineers have developed a new way to amplify the T-cell response to mRNA vaccines — an advance that could lead to much more powerful cancer vaccines and stronger protection against infectious diseases.

In studies in mice, this mRNA-encoded adjuvant enabled the immune system to completely eradicate most tumors, either on its own or delivered along with a tumor antigen. The adjuvant also boosted the T-cell response to vaccines against influenza and Covid-19.

The researchers tested the immune-remodeling mRNAs in several mouse models of cancer, including an aggressive bladder cancer, colon carcinoma, melanoma, and metastatic lung cancer. In nearly all of these mice, the injected mRNA stimulated a strong T-cell response that significantly slowed tumor growth and in many cases completely eradicated the tumors. This happened even when the mice were not given a vaccine against a specific cancer antigen. When they were, the response was even stronger.

https://www.nature.com/articles/s41587-026-03115-2

Every time I read cured cancer in mice my brain does that little here we go again thing

The immune system angle feels bigger than the headline though. If they can keep getting stronger T cell responses without wrecking people with side effects, that changes the mood around this stuff a bit