Neue psychedelisch-ähnliche Medikamente könnten Depressionen behandeln, ohne dass man stolpert

UC Davis researchers created a new class of psychedelic compounds using UV light and amino acid derived molecules. The drugs strongly activate 5-HT2A serotonin receptors linked to neuroplasticity but did not cause hallucination effects in mice.

From the Article: „Laboratory and computational studies showed that these molecules can partially or fully activate serotonin signaling pathways linked to both brain plasticity and hallucinations, while experiments in mice demonstrated suppression of psychedelic-like responses rather than their induction.“

Wow..amazing how far they are taking enshittification

Isn’t a huge part of psychedelics being helpful the trip itself? That it puts you in a state where you can more easily process and integrate stuff?

And on top of that, fully trigger serotonin to me makes me think of why not use MDMA which has been shown to have a lot of good affects when used in a therapy modality. 

The novelty of psychedelics can’t be overstated…I’ve had my share of good and bad trips. But ultimately, if you want bliss, you just want to dial down that left side of your brain for a while. If these meds can do that without drama or ceremony, that’s a good thing.

I think they misunderstand the nature of the psychedelic experience.
The spiritual and introspective and ‘trippy’ part of the experience are the most conducive towards true healing ❤️‍🩹

Excellent news for children and those that don’t partake.

Edit: Go ahead, explain it to me. Why the hell is relief bad?

Why are redditors so obsessed with psychedelics? Is this the new „cool“ thing here after weed?

Our culture treats drugs like they are immoral if they have recreational value. Quite being a little bitch and just eat the fuckin mushroom. Its supposed to be weird. The full experience adds so much. I mean, Im sure a non-psychoactive substance that helps with neuroplasticity is a good thing, too…but the psychedelic headspace itself is also very beneficial

So as someone that’s taken psychs and enjoyed their benefits. A lot of ya’ll saying it’s not worth it without the trip clearly haven’t experienced legitimate absences of medically resistant depression for up to three months because of psychs.

If that can be achieved without the committing to an eight if not up to sixteen hour experience, that’s a win.

I love psychs, love their benefits. I have to much shit to do to trip as often as my depression would like. This would be interesting.

So this will be to be made to ‚distract‘ people who might be needed to have a ‚clear‘ mind to tackle very ‚big‘ challenges for our future, or will this ‚really work‘ the way we hope?

Dang it, science! Make things MORE fun, not less fun!

Not sure how they could be called psychedelics then. If that’s the definition of new psychedelics, then you might as well add most other drugs too.

Why not just legalize the drugs the way they are the same way they did weed. Make it recreational for all to enjoy. Taking the magic out of it and selling it back to people sounds kinda lame.

Nah I’m good. Tripping is how you learn to be introspective and recognize the beauty in the world which leaves a permanent impact on your psych. Of course these brainiacs at billion dollars pharmaceutical companies don’t understand that.

The trip is what treats the depression.

It might be more of a matter of stepping outside of the ego, the hallucinations, the idea of being away from the body and its concerns for a bit to give a perspective.

I say this, having tried mushrooms, and that having had some positive effect. I say this having tried ketamine.

I say this as someone who is married to a ketamine addict who initially took it and got addicted to it to treat depression. Who tried to claim that it was adjusting their neurological plasticity as per research to that effect but wound up using it so much, so long, that they have diminished cognitive function, which there is research to that effect too, but not as touted as the anti-depressant research that sells more ketamine. After a couple years of chronic use one gets brain lesions and cognitive impairment, like dementia. It is not a thing to be done therapeutically, it is not increasing plasticity, it is the trip, the stepping out side of the ego, once, or once a year at most, that does it.

I haven’t had a bad trip personally, except the ones where I took my spouse to the ER or rehab. And those weren’t bad trips per se, but for psychological reasons, like k-cramps to the ER, and unable to eat or soiling the bed for the rehabs.

I doubt these researchers know what the mice are feeling. They are missing the point trying to quantify an almost entirely subjective experience, and in mice. If we want to treat depression, first we need an objective test for it, and none exists, so it is dubious that they can say this would treat depression. I doubt that if this came to be a product, that it would have any more effect than any other anti-depressant, that mainly works because people believe it does, and doesn’t work more than half the time. They’re selling hope here, which is the precursor to selling drugs, and about the only thing that makes anti-depressants work.

I do not believe we know enough about neuroscience to create an effective drug, like Aldous Huxley’s „Soma“ that will make us happy workers.

The thing that is causing our depression is this constant existential dread, that we have to work or die. That consumption will make us happy, and when it doesn’t it is because we did not consume enough, so we have to work harder to consume more, but that makes us unhappy so we have to work harder to consume more until we can’t afford to consume more, and the consumption and the work make us feel empty. The cure for that is not another newer better drug to consume, that is just more.

If you can step outside of that for a moment, realize time is an illusion, another plane exists, then maybe you can see it for what it is, and it won’t be so dire to you. But you can’t do that without a trip, a trip you could take without drugs. If you do use the drugs, realize that plane is timeless, it exists even as you move through time, and you don’t have to keep revisiting it because it is always there.

Don’t do drugs kids. Even the ones that mother gives you, that seem to do nothing at all, can do bad things to you. Or believe in it, and maybe it works for you for believing in it. You do you.