Gen-Editierungen, die als Base-Editing bekannt sind, könnten Hindernisse bei der Behandlung solider Tumorkrebsarten wie Lungen-, Brust- und Nierenkrebs mit der CAR-T-Zelltherapie beseitigen, finden Forscher.

No scientists were consulted in the writing of this article

>But he has collaborated with colleagues to overcome this critical barrier by using a type of genetic engineering known as base editing – a precise gene-editing technique that makes targeted changes to molecular DNA.

That’s like saying that a revolutionary new EV will change the world because it has wheels. Editing the genetic makeup of T cells is the basis of CAR-T therapy. The novel development here is their

>multifaceted approach to engineer allogeneic CAR T-cells resistant to both biochemical (hypoxia-adenosinergic) and immunological (PD-L1 and TGF-β) inhibitory signaling using an adenine base editor and a CRISPR-Cas12b nuclease. The resulting EGFR-targeting CAR T-cell product comprised a combination of six gene edits designed to evade allorejection (B2M, CIITA), prevent graft-versus-host disease (CD3E) and overcome biochemical (ADORA2A) and immunological (PDCD1, TGFBR2) barrier