Niedrige LSD-Dosen verändern die emotionalen Gehirnreaktionen bei Menschen mit leichter Depression. Untersuchungen weisen auf spezifische Veränderungen der elektrischen Gehirnaktivität nach der Verabreichung einer kleinen Dosis bei Patienten mit leichter Depression hin.

>A new [study](https://journals.sagepub.com/doi/10.1177/02698811251405686) suggests that low doses of the psychedelic drug lysergic acid diethylamide, better known as LSD, can enhance how the human brain processes emotional rewards. The research, published in the Journal of Psychopharmacology, points to specific shifts in electrical brain activity following the administration of a small dose in patients experiencing mild depression. These neural changes corresponded with an improved mood that lasted for days after the initial exposure.

>For years, public interest has grown around the practice of taking very small, barely perceptible amounts of psychedelic drugs. Often referred to as microdosing, this habit is frequently touted by advocates as a way to elevate mood, enhance creativity, and improve mental focus. Taking tiny amounts of LSD every few days has become especially popular among those seeking alternative ways to manage depression.

>Yet proving the benefits of microdosing under controlled laboratory conditions has proven difficult. Subjective self-reported mood questionnaires sometimes fail to capture subtle biological changes happening beneath the surface. To bypass these limitations, researchers are turning to direct measurements of electrical activity in the brain. They suspect that tracking exact neural responses to rewards might reveal biological shifts that typical subjective measures easily overstate or miss completely.