Wissenschaftler haben einen großen Schritt in Richtung der Entwicklung eines sicheren, reversiblen, langwirksamen und 100 % wirksamen nichthormonellen Verhütungsmittels für den Mann getan. Eine Proof-of-Prinzip-Studie an Mäusen, an der sechs Jahre gearbeitet wurde, zeigt, wie die Spermienproduktion sicher gestoppt werden konnte, indem man gezielt auf den Prozess der Fortpflanzung von Geschlechtszellen abzielte.
https://news.cornell.edu/stories/2026/04/breakthrough-takes-big-step-toward-safe-reversible-male-contraception
7 Kommentare
Cornell scientists have taken a major step toward developing a safe, reversible, long-acting and 100% effective nonhormonal male contraceptive, considered the holy grail of male contraception.
A proof of principle study in mice, six years in the making, shows how targeting a natural checkpoint in meiosis, the process by which sex cells reproduce, safely stopped sperm production.
The researchers made use of JQ1, a small molecule inhibitor that was developed as a research tool to study cancer and inflammatory disease. Because of its neurological side effects, it wasn’t a viable therapy for disease, or as a final contraceptive, but it’s known to disrupt a stage of meiosis called prophase 1. This enabled Cornell researchers to provide the first proof of principle that meiosis – and sperm production – can be targeted safely and reversibly.
For those interested, here’s the link to the peer reviewed journal article:
https://www.pnas.org/doi/10.1073/pnas.2517498123
im looking foward to the ADAM gel injection, it seems less scary to me than some molecule that impacts my sex cells (even if this fear is unfounded)
The title might be a little misleading. It attempts to prove a specific biological target for developing male contraceptives.
From the abstract: „While acknowledging the need for robust future safety assessments of any candidate drugs, these studies provide a blueprint for developing new contraceptive approaches that act safely and selectively within the germline.“
This is a space with many attempted targets that have largely failed due to causing significant side effects. An interesting study for sure, but before we get too excited, I think that’s important to keep in mind.
I don’t want to downplay how cool this is but it’s been every decade since I was born. Sell a pill already.
The real question will be its effects on testosterone, and if they somehow increase it, whether or not it’ll „turn off your balls“ so to speak, as anabolics do.
That’s interesting, and this does seem to be a new mechanism. But I’m skeptical about its future as a real option, because we’ve had various vasalgels in clinical trials for about 25 years, and they’re always just 2-3 years of safety trials away.
still waiting on my fucking vasalgel.