Neurowissenschaftler haben zum ersten Mal gezeigt, dass nichtinvasive Hirnstimulation die Aktivität einer kritischen tiefen Hirnregion verändern kann, die an Emotionen und Gedächtnis beteiligt ist. Wir ebnen den Weg zur personalisierten, nichtinvasiven Hirnstimulation

>Moreover, the study shows that personalizing the stimulation site using a patient’s unique brain connectivity pathway can increase the neuromodulation effect.

>The hippocampus is a deep brain region that plays a critical role in multiple brain functions, such as memory and emotion. Problems with hippocampal function have been implicated in several neurological and neuropsychiatric conditions including Alzheimer’s disease, depression, anxiety, and post-traumatic stress disorder (PTSD).

>Rather than stimulating the same brain location in every individual, the researchers were able to tailor the stimulation site based on each person’s unique brain connectivity in four patients. Resting-state functional magnetic resonance imaging (fMRI) was used to trace the unique hippocampal connectivity map in each person’s brain. This information helped identify individualized TMS-accessible sites in the cortex that were most strongly connected to the hippocampus.
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>The researchers found that stimulating these individualized cortical sites, with either single-pulse TMS, or with repetitive TMS that is widely used in clinical treatment, preferentially elicited evident activity changes in the hippocampus. In the other four patients whose stimulation sites were not personalized with patients’ unique brain connectivity, no robust activity changes were observed in the hippocampus.
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>These findings were complemented with evidence from a noninvasive experiment that used TMS concurrently with fMRI to measure activity changes in the hippocampus in 79 neurologically healthy participants.

[Multimodal evidence for hippocampal engagement and modulation by functional connectivity-guided parietal TMS | Nature Communications](https://www.nature.com/articles/s41467-026-70346-x)