Gelegentlicher starker Alkoholkonsum kann das Risiko einer Leberschädigung verdreifachen: Bei Personen, die mindestens einmal im Monat an einem einzigen Tag große Mengen Alkohol konsumieren, ist die Wahrscheinlichkeit, eine fortgeschrittene Leberfibrose zu entwickeln, dreimal höher als bei Personen, die den gleichen Gesamtalkoholkonsum über einen längeren Zeitraum verteilen
https://news.keckmedicine.org/occasional-heavy-drinking-may-triple-the-risk-of-liver-damage/
11 Kommentare
> Lee and his colleagues used data from the nationally representative National Health and Nutrition Examination Survey, a long-running health survey of the United States population. They included data from more than 8,000 adults, collected between 2017 and 2023. In particular, they looked at the link between episodic heavy drinking and advanced liver fibrosis to understand how drinking patterns — not just total drinks — may cause harm even to moderate drinkers, which is considered seven drinks a week for women and 14 or less for men.
>More than one-half of the adults included in the study reported episodic heavy drinking and almost 16% of patients with MASLD were episodic heavy drinkers.
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>The researchers compared people with MASLD with the same age, sex and average weekly alcohol consumption, segmenting some as episodic heavy drinkers and others as non-episodic heavy drinkers, to reach their conclusion that episodic heavy drinkers with MASLD had nearly three times higher odds of experiencing advanced liver fibrosis.
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>Lee speculates that episodic heavy drinking can harm the liver both directly and indirectly. Drinking large amounts of alcohol at once can overwhelm the liver and increase inflammation, which leads to scarring and damage. People with MASLD may be particularly at risk, as Lee’s previous research has shown that obesity, high blood pressure and other conditions associated with MASLD can more than double liver disease risk.
[Episodic Heavy Drinking and Implications for Steatotic Liver Disease Nomenclature: A National Cross-Sectional Study – Clinical Gastroenterology and Hepatology](https://www.cghjournal.org/article/S1542-3565(26)00163-1/abstract)
Thats how poisons and tolerance work. Makes sense.
>Episodic heavy drinking was ≥4 drinks (women) and ≥5 (men) on any day, at least once per month.
Since it feels like this is something everyone is going to want to know.
Also worth pointing out that this study is only considering people that already have MASLD for the headline statistic.
I wonder if this could be due (at least partially) to the toxic metabolites of alcohol, such as acetaldehyde. After a certain point, I imagine that the enzymatic processes to degrade these metabolites get overwhelmed, causing more of these byproducts to build up.
This seems similar to processing of Tylenol, as the initial byproduct is quite toxic but is converted to a more benign substance through a specific enzymatic process. That is, assuming you haven’t OD’d on Tylenol or have significant alcohol in your system, which results in the acute buildup of the toxic metabolite leading to potentially catastrophic damage.
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The good news is if you stop drinking before you have serious complications the liver is outstanding at regenerating and healing itself
Based on my experience, if you drink too much on the weekends, drink less on the weekend. Don’t try to „spread it out“ based on retrospective studies like this
Hope my buddies can get off the bottle cause it ain’t looking good at age 29 rn.
I had a grandfather who drank a bottle of scotch a day for 30 years.
Had to be given alcohol in the nursing home so his blood didn’t thicken up so much that it killed him.
Everyone in reasonable good health has the potential for good years into their late 70’s give or take a decade.
I party with degenerate
people in their 60’s, 70’s and 80’s , heavy users.
It takes a lot to kill a person, until it doesn’t and individual susceptibility has a lot to do with that.
No mention of wisconsin, sad. So what happens when binge drinking is just a casual Saturday? Or is like our 4 – 5 beers for an easy night considered binge drinking too?
We get it, science posts anti alcohol stuff for clout. I’m not saying go get drunk, I’m just saying I’m tired of reading the same article over and over again.