Wissenschaftler entdecken einen Schaltkreis im Gehirn, der die körperliche Ausdauer steigert. Eine Studie an Mäusen hat ein entscheidendes Signal im Zentralnervensystem gefunden, das dabei hilft, die körperliche Ausdauer im gesamten Körper nach wiederholtem Training aufzubauen.
https://www.sciencealert.com/scientists-discover-a-brain-circuit-that-enhances-physical-endurance-in-mice
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>The effects of exercise would not be nearly as powerful without the input of the brain, according to new research.
>A [study](https://doi.org/10.1016/j.neuron.2025.12.033) on mice has found a critical signal in the central nervous system that helps build physical endurance in the wider body after repeated exercise.
>Traditionally, scientists thought that our body’s extensive response to frequent exercise occurred mainly in the periphery, such as the bones and muscles, and the heart.
>But researchers in the US, led by experts at the University of Pennsylvania, think that the brain is key to remodeling our bodies for great physical activity.
>Their evidence among mice suggests that specific signals in the central nervous system are „enhancing exercise endurance and coordinating peripheral metabolic adaptations.“
>In their experiments, mice that had run on a treadmill showed increased activity within neurons located in their ventromedial hypothalamus (VMH). This part of the brain is involved in balancing the body’s energy expenditure against its needs.
>The neurons that were most active following exercise, called steroidogenic factor-1 (SF1) neurons, remained so for at least an hour after the mice had finished running.
So the brain is a key player in exercise, and exercise is the single best thing you can do for brain health.
Seems like there can be positive feedback loops here that either are really good or really bad for you.