Gehirnnetzwerk für wirksame Behandlung der Parkinson-Krankheit identifiziert: durch Modulation mit Tiefenhirnstimulation (DBS) eines spezifischen Gehirnnetzwerks, das hauptsächlich im schnellen Beta-Frequenzbereich (20 bis 35 Hz) aktiv ist.
https://www.uni-koeln.de/en/university/news/news/news-detail/brain-network-identified-for-effective-treatment-of-parkinsons-disease
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> „For the first time, we were able to characterize the DBS response network in Parkinson’s disease in terms of space and time, simultaneously,“ says Professor Dr Andreas Horn from the University of Cologne, who led the study and specializes in computational neurology. „We show that Parkinson’s disease can best be treated if we stimulate a very precisely defined network. This network operates synchronized within a specific frequency band, and offers an explanation for how well patients respond to deep brain stimulation.“
>The research team analysed data from a large multi-centre cohort with one hundred brain hemispheres from fifty patients. Using brain signals that were simultaneously recorded via the implanted DBS electrode and magnetoencephalography (MEG), the scientists mapped the functional connectivity between the deep and superficial areas of the brain.
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>The study showed that the relevant network between the subthalamic nucleus and frontal brain regions largely communicates at a comparatively fast frequency (20-35 Hz). The strength of this connection explains how well the motor symptoms of individual patients improved after electrode implantation.
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>“These results suggest that a certain rhythm of the brain acts as a communication channel between the subthalamic nucleus and the cerebral cortex and may mediate the therapeutic effects of deep brain stimulation,“ explains Dr Bahne Bahners, first author of the study, who works at Düsseldorf University Hospital. „By stimulating regions that are connected to the identified network, we will probably be able to adjust DBS settings more precisely in the future, especially in patients who have not yet benefited optimally from deep brain stimulation.“
[deep brain stimulation response network in Parkinson’s disease operates in the high beta band | Brain | Oxford Academic](https://academic.oup.com/brain/advance-article-abstract/doi/10.1093/brain/awaf445/8454290?redirectedFrom=fulltext)
This study seems to lack a control group, which means the observed outcomes could be influenced by participants’ expectations — in other words, a placebo effect cannot be ruled out. At the same time, we know that the brain’s structure and connectivity are constantly changing in response to psychosocial experiences. With this in mind, research indicates that practices such as mindfulness meditation and yoga can meaningfully improve anxiety, inflammation, motor symptoms, and overall quality of life for people with Parkinson’s disease. See for example the following randomized clinical trial: [https://pubmed.ncbi.nlm.nih.gov/40024243/](https://pubmed.ncbi.nlm.nih.gov/40024243/)