Eine einzige Trinkexzesse kann bei gesunden Erwachsenen die Darmschleimhaut schwächen, wodurch Bakterien und Giftstoffe in den Blutkreislauf gelangen können, ein Phänomen, das laut einer Studie im Tiermodell als „Leaky Gut“ bekannt ist

>Research shows that a single drinking binge — roughly four drinks for women or five for men within about two hours — can disrupt the gastrointestinal tract in measurable ways. Even in healthy adults, such a rapid influx of alcohol can weaken the gut lining, making it less able to perform one of its core jobs: keeping bacteria and toxins from entering the bloodstream, a phenomenon known as “leaky gut.”

>Certain immune cells, called neutrophils, can release web-like structures known as NETs that directly damage the upper small intestine and weaken its barrier, helping explain the “leaky gut” that can let bacterial toxins slip into the bloodstream.
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>When the researchers blocked the NETs using a simple enzyme to break them down, they observed a reduced number of immune cells in the gut lining and less bacterial leakage; that is, the enzyme prevented gut damage.
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>“We know that excessive drinking can disrupt the gut and expose the liver to harmful bacterial products, but surprisingly little was known about how the upper intestine responds in the earliest stages,” said corresponding author Gyongyi Szabo, MD, PhD, who is also Chief Academic Officer at BIDMC and Beth Israel Lahey Health. “Our study shows that even short bouts of binge drinking can trigger inflammation and weaken the gut barrier, highlighting a potential early step in alcohol-related gut and liver injury.“

[Unraveling the gastrointestinal tract’s response to alcohol binges: Neutrophil recruitment, neutrophil extracellular traps, and intestinal injury – Minchenberg – 2025 – Alcohol, Clinical and Experimental Research – Wiley Online Library](https://onlinelibrary.wiley.com/doi/10.1111/acer.70196)

I don’t know how scientific this is, but after Fri/Sat heavy drinking, taking a dump felt like getting rid of poison.

Remember when “leaky gut” was known as pseudoscience disorder, without much real evidence? Sure there was intestinal permeability but that didn’t necessarily line up the colloquial usage of leaky gut. 

Not looking so much like pseudoscience anymore

Did anyone need to know this? It clutters your brain when you could be spending this time getting hammered into oblivion. I think we’re getting to the point of knowing too much

I remember how the leaky gut syndrome was something that Andrew Wakefield proposed as part of the pathway that leads to the MRR vaccine causing autism in children.

The entire scandal about his „paper“ makes me very suspicious whenever someone puts forth the leaky gut syndrome as the leading cause for anything. This unfortunately isn’t my area of expertise, so I’d appreciate some expert opinion on this.

I was a binge drinking alcoholic from 16 to 29. Basically once a week for 12 to 24 hours I would consume a very large amount of alcohol 

I got sober at 29, and was diagnosed with stage 3 colon cancer at 32. I have little doubt binge drinking had a major factor in my development of cancer. I have no family history or genetic predisposition for cancer

Today I am 6.5 years sober and 3 years out from surgery/ chemotherapy.

I hope to never take another drink in my life. I work towards that goal everyday 

NS street 1st we awash a 22nd

After 30 cooler ranch Doritos impact my gut lining.

This makes me think of what happens to people that drink more than this in a longer period of time…. like for instance some times ill have 6 beers but its over the course of the whole night so maybe like 7 hours or something like that. Is it not as bad for you because youre not saturating your bloodstream as fast?