Umfangreiche genetische Studie deckt verborgene Zusammenhänge zwischen psychiatrischen Erkrankungen auf. Eine Genomanalyse von mehr als einer Million Menschen legt nahe, dass die meisten schwerwiegenden psychiatrischen Erkrankungen gemeinsame biologische Wurzeln haben.
https://www.nature.com/articles/d41586-025-04037-w
3 Kommentare
Excerpt:
>Psychiatrists have long relied on diagnostic manuals that regard most mental-health conditions as distinct from one another — depression, for instance, is listed as a separate disorder from anxiety. But a genetic analysis of more than one million people suggests that a host of psychiatric conditions have common biological roots.
>The results, published today in Nature, reveal that people with seemingly disparate conditions often share many of the same disease-linked genetic variants. The analysis found that 14 major psychiatric disorders cluster into five categories, each characterized by a common set of genetic risk factors. The neurodevelopmental category, for example, includes both attention deficit hyperactivity disorder and autism, which psychiatric handbooks classify as separate conditions.
>Many supposedly individual conditions are “ultimately more overlapping than they are distinct, which should offer patients hope”, says study co-author Andrew Grotzinger, a psychiatric geneticist at the University of Colorado Boulder. “You can see the despair on someone’s face [when] you give them five different labels as opposed to one label.”
I’m the reporter who wrote this piece. Happy to answer any questions about how I reported it, or hear if there’s anything else that should be on my radar for future coverage. My Signal is mkozlov.01.
Link to original research paper: [https://www.nature.com/articles/s41586-025-09820-3](https://www.nature.com/articles/s41586-025-09820-3).
I love how science disproves superstitious notions like some people are born evil. What we are proving, is that the „different“ and „mentally ill“ behaviors or thoughts of people can be traced to actual scientific biological differences.
Which essentially means, it will be possible to both treat and cure „evil“. No need to believe in metaphysics, instead we just need to trust medicine, neurology, psychology, and modern science and keep striving to find that cure.
Even though there may be a narrow range of underlying genetic factors, it doesn’t invalidate that diverse disorders can manifest through experience and epigenetic changes.
Yup, there may be underlying hyperactivity re fear sensitivity regulation but this can manifest as an anxiety disorder, depressive hopelessness, or rigid obsessional compulsive coping, depending on experience and social and individual factors.
There may be implications for psychiatric treatments, but continuing to recognize the diversity in presentations and psychological treatments may be important