Forscher zeichnen einen zellulären Bauplan dafür, wie wir denken und fühlen. Es zeigt, wie bestimmte Gehirnnetzwerke als Vermittler fungieren und die mikroskopische Biologie des Gehirns (wie bestimmte Zelltypen) mit komplexen Verhaltensweisen und mentalen Prozessen verbinden.

A new study from experts with Georgia State University has achieved a long-standing goal in neuroscience: showing how the brain’s smallest components build the systems that shape thought, emotion and behavior.

The research, published in the journal Nature Communications, could transform how scientists understand cognition and aging, as well as mental health disorders like depression and schizophrenia.

By combining brain scans with genetic data and molecular imaging, the researchers have uncovered a detailed biological map linking different levels of the brain and revealing the long-sought bridge between micro- and macro-level brain organization.

Vince Calhoun is a Distinguished University Professor with Georgia State and a Georgia Research Alliance Eminent Scholar with faculty appointments at Georgia Tech and Emory University. He leads the collaborative tri-institutional Center for Translational Research in Neuroimaging and Data Science, or TReNDS Center, and is a senior author on the study.

“We found that the brain’s large-scale networks are built on a hidden biological blueprint. By aligning data from cells, molecules and imaging, we showed that the same architecture seen in fMRI is rooted in cellular and molecular organization,” Calhoun said. “Each dataset alone gives part of the story. Together, they reveal how chemical and cellular gradients actually help wire the brain’s networks.”

https://www.nature.com/articles/s41467-025-66291-w