Einer der Vorteile des Gehirns durch Bewegung, die Entstehung neuer Neuronen, erfordert möglicherweise keine Bewegung. Extrazelluläre Vesikel, die nach dem Training im Blut zirkulierten, wurden erfolgreich von Mäusen, die Sport trieben, auf Mäuse übertragen, die sich nicht bewegten, was zu einer Zunahme neuer Zellen führte, von denen sich 89,4 % in Neuronen differenzierten.

We may not need to exercise to get the same neuron boost as a workout

One of the brain’s biggest benefits from exercise – the birth of new neurons – may not even require any movement. Instead, the beneficial “packages” circulating in the blood after working out can be successfully transferred to others.

When we exercise, thousands of molecules are released into the bloodstream – including extracellular vesicles (EVs), microscopic packages filled with proteins, RNA, fats and other signaling molecules. These are also small enough to cross the blood-brain barrier to trigger neurogenesis – the growth of neurons – in the hippocampus. But a key question remained: would these exercise-stimulated vesicles still work if you delivered them to someone who hadn’t exercised at all?

Researchers at the University of Illinois Urbana-Champaign have now answered that, demonstrating that these extracellular vesicles (EVs) can be taken from one body to another without losing their power.

Adult male mice were given constant access to running wheels for four weeks, while another group was kept sedentary with their wheels locked in place. At the end of the four weeks, the team collected blood from both groups and isolated EVs, which were separated into two samples, exercise-derived EVs (ExerVs) and sedentary-derived EVs (SedVs).

Another set of sedentary mice were then randomly assigned to receive either the ExerV or SedV preparation or a placebo injection (phosphate-buffered saline). The scientists found that sedentary mice that had received the ExerVs transfusion showed a significant increase in the density of new cells – and 89.4%of these new cells had differentiated into neurons (NeuN).

For those interested, here’s the link to the peer reviewed journal article:

https://www.sciencedirect.com/science/article/pii/S0006899325005669