
Forscher am MIT haben gerade ein neues Lipid-Nanopartikel entwickelt, das die Wirksamkeit des mRNA-Impfstoffs bei Mäusen auf das Hundertfache seiner Einzelwirksamkeit steigert und so durch die Reduzierung der erforderlichen Dosierungen massive Einsparungen ermöglicht und gleichzeitig die Toxizität in der Leber verringert.
https://newatlas.com/medical-tech/nanoparticle-mrna-vaccine-cheaper-more-powerful/
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I’ve linked to the news release in the post above. In this comment, for those interested, here’s the link to the peer reviewed journal article:
https://www.nature.com/articles/s41565-025-02044-6
From the linked article:
New nanoparticle mRNA vaccine may be cheaper and 100 times more powerful
**Researchers at MIT have just developed a new lipid nanoparticle that super-enhances the effectiveness of the mRNA vaccine in mice to a hundred times its stand-alone effectiveness, thus offering massive savings by reducing required dosages while also reducing toxicity in the liver**.
The result is their nanoparticle-enhanced mRNA vaccine that, unit-per-unit, does the work of a hundred times as much of the FDA-approved ionizable lipid SM-102. Even better, lower dosages also “substantially reduced expression in the liver following intramuscular injection, mitigating the associated toxicity.”
A new family of ionizable lipids – neat! This space is ripe for innovation. A lot of LNP developers are unwilling to put in the work needed to get new lipids approved by the FDA due to regulatory risk and IP privacy concerns
hold up, podna, we don’t do that mDNA thing here in ‚merica.
RFK jr: Poison!!! Autism!!!