Forscher am MIT haben gerade ein neues Lipid-Nanopartikel entwickelt, das die Wirksamkeit des mRNA-Impfstoffs bei Mäusen auf das Hundertfache seiner Einzelwirksamkeit steigert und so durch die Reduzierung der erforderlichen Dosierungen massive Einsparungen ermöglicht und gleichzeitig die Toxizität in der Leber verringert.

    https://newatlas.com/medical-tech/nanoparticle-mrna-vaccine-cheaper-more-powerful/

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    4 Kommentare

    1. I’ve linked to the news release in the post above. In this comment, for those interested, here’s the link to the peer reviewed journal article:

      https://www.nature.com/articles/s41565-025-02044-6

      From the linked article:

      New nanoparticle mRNA vaccine may be cheaper and 100 times more powerful

      **Researchers at MIT have just developed a new lipid nanoparticle that super-enhances the effectiveness of the mRNA vaccine in mice to a hundred times its stand-alone effectiveness, thus offering massive savings by reducing required dosages while also reducing toxicity in the liver**.

      The result is their nanoparticle-enhanced mRNA vaccine that, unit-per-unit, does the work of a hundred times as much of the FDA-approved ionizable lipid SM-102. Even better, lower dosages also “substantially reduced expression in the liver following intramuscular injection, mitigating the associated toxicity.”

    2. A new family of ionizable lipids – neat! This space is ripe for innovation. A lot of LNP developers are unwilling to put in the work needed to get new lipids approved by the FDA due to regulatory risk and IP privacy concerns 

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