Gemeinsame Ungleichgewichte der Darmmikroben bei Autismus, ADHS und Anorexia nervosa: Eine neue Studie hat unterschiedliche Muster in den Darmbakterien von Kindern und Jugendlichen mit Autismus-Spektrum-Störung, Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung und Anorexia nervosa identifiziert.
Shared gut microbe imbalances found across autism, ADHD, and anorexia nervosa
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I’ve linked to the news release in the post above. In this comment, for those interested, here’s the link to the peer reviewed journal article:
https://www.ibroneuroscience.org/article/S0306-4522(25)00860-7/abstract
From the linked article:
**Shared gut microbe imbalances found across autism, ADHD, and anorexia nervosa**
**A new study has identified distinct patterns in the gut bacteria of children and adolescents with autism spectrum disorder, attention-deficit/hyperactivity disorder, and anorexia nervosa**. Published in the journal Neuroscience, the research also reveals altered levels of hormones that regulate appetite, suggesting a complex interplay between gut microbes, eating behaviors, and brain health in these conditions.
The analysis revealed several commonalities among the patient groups when compared to healthy controls. All three patient groups, those with ASD, ADHD, and AN, showed a higher ratio of two major groups of bacteria, known as Bacteroidetes to Firmicutes. This ratio is often considered an indicator of the overall balance of the gut ecosystem. Patients across the three disorders also tended to have lower levels of beneficial bacteria such as Bifidobacterium and Faecalibacterium.
Beyond these shared characteristics, each condition was associated with a unique microbial signature. Children with ASD and ADHD both had lower overall bacterial richness, meaning a less diverse community of microbes in their guts. The ASD group had higher levels of Bacteroidetes and Escherichia-Shigella bacteria and lower levels of Actinobacteriota and Ruminococcus.
Similarly, the ADHD group showed an increase in Escherichia-Shigella and a group called Desulfovibriota, along with a decrease in Firmicutes. The adolescents with AN also had lower levels of Firmicutes but showed elevated levels of several other bacterial groups, including Proteobacteria, Cyanobacteria, and Verrucomicrobiota.
When the researchers examined the appetite-regulating hormones, they found notable differences. Children with ADHD had significantly lower levels of PYY, a hormone that helps signal fullness after a meal. The changes were more pronounced in the group with AN, where participants had lower levels of leptin, ghrelin, and PYY compared to their healthy counterparts. The researchers did not find significant differences in markers of intestinal inflammation or in the levels of nerve-growth factors among the groups.
Kids need to eat dirt.
Seriously. Aside from fact that ADHD and autism spectrum is more of description of symptoms, not one or two distinct causes, the gut bacteria is greatly influenced by the environment.
In contrast to brain chemistry, not to speak about genetic predisposition – we can have great impact on bacteria biom.
ELI5 – can a probiotic potentially cure or treat these things. Asking for a gut I know.
Neuroimmunology and immunopsychiatry exist, its just that there are no clinicians and the clinical world just ignores decades of science. Psychiatry is obsolete. It is all neurology of some kind.
Are there any prebiotic or probiotic suggestions to mitigate adhd and autism in children?
Would the hope be that they have it less pronounced as adults post intervention?
This makes sense, these groups can have extreme texture sensitivity and might seek out a less nutritionally complete diet in response.
My heart dropped reading this title though, cuz this is definitely going to be used by pro-Wakefield anti-vaxxers. There’s gotta be a more responsible way to present this information.
Interesting, I suspect the neurological difference causes the imbalance, probably why people with ADHD find glp1 medication actually helps with their ADHD.
Would be nice to know if there’s a huge probiotic diet we can use to promote the good bacteria ratio, so hard to find fecal transplant in the UK.
Time to make some yogurt…