Forscher haben eine innovative Methode entwickelt, bei der ein Stammzellpflaster verwendet wird, um beschädigte Herzen ohne Operation am offenen Herzen zu reparieren. Dieses Pflaster wird durch einen winzigen Einschnitt verabreicht und stellt einen bahnbrechenden Durchbruch dar, der möglicherweise die Behandlung von Herzinsuffizienz revolutionieren könnte

>In collaboration with engineers at the University of Nebraska Medical Center, Mayo researchers developed a flexible, paper-thin patch made of nano- and microfibers coated with gelatin. This hybrid scaffold supports a blend of human heart muscle cells, blood vessel cells and fibroblasts—cells that form the tissue’s structural framework—to create a living, beating piece of heart tissue. Before transplantation, the tissue is infused with bioactive factors such as fibroblast growth factor 1 and CHIR99021 that encourage the growth of new blood vessels and help the cells survive once they are in place.
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>“The beauty of this design,“ says Dr. Zhu, „is that it can be folded like a piece of paper, loaded into a slender tube, and delivered precisely where it’s needed through a small incision in the chest. Once in place, it unfolds and adheres naturally to the heart’s surface.“
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>Instead of using stitches, the team used a biocompatible surgical adhesive that holds the patch in place while minimizing additional trauma to the surrounding tissue.
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>Testing in preclinical models showed that the minimally invasive method improved heart function, reduced scarring, enhanced vascular growth and lessened inflammation compared with conventional approaches.
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>“Our results show that these engineered tissues not only survive but actually help the heart heal itself,“ says Dr. Zhu. „That’s the ultimate goal: to replace what’s lost and restore function.“
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[Minimally invasive delivery of engineered heart tissues restores cardiac function in rats with chronic myocardial infarction – ScienceDirect](https://www.sciencedirect.com/science/article/abs/pii/S174270612500649X)