Die Exposition von Mäusen gegenüber PFAS-„Ewig-Chemikalien“ verringerte den Testosteronspiegel und die Spermienproduktion und brachte Embryonen mit „abnormaler Genexpression“ hervor.

From the linked article:

Despite **significant bioaccumulation** in the blood plasma and testes of exposed animals, consumption of the PFAS cocktail **did not elicit overt cytotoxicity or genotoxicity** within either the somatic or germ cells of the male reproductive tract.

However PFAS exposure **significantly reduced the rate of daily sperm production**, likely due to **decreased circulating testosterone and dihydrotestosterone**. Further, PFAS-exposed spermatozoa displayed marked alterations to their small non-coding RNA profile, which were linked to **dysregulation of early-embryonic gene expression**. Notably, these changes occured **without significant alteration** in sperm viability, motility, or the ability to undergo capacitation or support embryonic development.