Das Abnehmmedikament Semaglutid senkt das Risiko eines Herzinfarkts oder Schlaganfalls, unabhängig davon, wie viele Kilogramm Menschen abnehmen, so die größte Studie dieser Art. Die Ergebnisse im Lancet deuten darauf hin, dass Medikamente über die Gewichtsabnahme hinaus weitere Vorteile für Patienten haben könnten und daher nicht auf die am stärksten fettleibigen Patienten beschränkt sein sollten.

I’ve linked to the news release in the post above. In this comment, for those interested, here’s the link to the peer reviewed journal article:

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01375-3/fulltext

From the linked article:

The **weight-loss drug semaglutide cuts the risk of heart attack or stroke regardless of how many kilograms people lose, the largest study of its kind has found**.

However, shrinking waist size – a sign of less belly fat – was linked to better heart outcomes, according to the research.

**The findings, published in the Lancet, suggest drugs could have wider benefits for patients beyond weight loss so should not be restricted to the most obese patients**.

Researchers set out to examine the additional benefits of semaglutide, which is the main ingredient of the weight-loss drug Wegovy.

The select trial, led by University College London (UCL), looked at whether or not people taking the drug went on to suffer a “major adverse cardiac event” – including heart disease deaths, heart attacks or strokes.

They examined data on 17,604 people aged 45 and over who were either overweight or obese.

Half of the people taking part in the study – which took place across 41 countries – were given weekly injections of semaglutide. The other half were given a dummy drug, known as a placebo.

Previous analysis of the data found that semaglutide reduced the risk of major adverse cardiac events by 20%. Researchers have now found the benefit was apparent regardless of how much weight people lost while taking the drug.

Academics said the findings suggested there were multiple ways the drug could benefit the heart, rather than the protective effect achieved solely by weight loss alone.