Forscher identifizieren Schlüsselgene, die mit dem Cannabiskonsum und seiner Häufigkeit verbunden sind, insbesondere CADM2 und GRM3, die mit der Kommunikation und Impulsivität des Gehirns verbunden sind. Die Studie deckte auch andere Gene auf, die mit Risikobereitschaft, Schizophrenie, Diabetes und koronarer Herzkrankheit in Zusammenhang stehen

> The research team conducted a genome-wide association study (GWAS) analyzing relationships between cannabis use and genetic data provided by 131,895 23andMe research participants. They answered survey questions about whether or not they had ever used cannabis, and those who answered yes were also asked how frequently they used the drug.

>The study found that lifetime cannabis use was associated with two genes. The first was Cell Adhesion Molecule 2 (CADM2), a gene involved in cell assembly and in signaling between nerve cells, particularly in the brain. Previous studies have linked CADM2 to various traits and conditions, including impulsive personality, obesity and cancer metastasis. Frequency of cannabis use was also found to be associated with the CADM2 gene.
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>The second gene was Metabotropic Glutamate Receptor 3 (GRM3), which is involved in communication between neurons and long-term brain plasticity. GRM3 has already been linked to psychiatric disorders, including schizophrenia and bipolar disorder.

>A secondary analysis revealed an additional 40 genes associated with lifetime cannabis use and four genes associated with frequency of cannabis use. Twenty-nine of these genes had not previously been associated with cannabis-related traits. 
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>The researchers then analyzed which health conditions were correlated with a genetic predisposition for cannabis use. They analyzed thousands of traits in two large independent datasets from the National Institutes of Health’s (NIH) All of Us Research Program and Vanderbilt University Medical Center’s biobank
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[Genome-wide association studies of lifetime and frequency of cannabis use in 131,895 individuals | Molecular Psychiatry](https://www.nature.com/articles/s41380-025-03219-2)

Can I get a gene test and see if I am… predisposed? to consuming cannabis?