Wissenschaftler entdecken einen Antikörper, der 98,5 % von mehr als 300 verschiedenen HIV-Stämmen neutralisiert, einen der am häufigsten identifizierten Antikörper gegen HIV. In Experimenten mit humanisierten Mäusen (deren Immunsystem so verändert wurde, dass es dem des Menschen ähnelt) reduzierte es die HIV-Viruslast dauerhaft auf nicht mehr nachweisbare Werte.

    https://www.uni-koeln.de/en/university/news/news/news-detail/antibody-discovered-that-blocks-almost-all-known-hiv-variants-in-neutralization-assays

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    3 Kommentare

    1. I’ve linked to the press release in the post above. In this comment, for those interested, here’s the link to the peer reviewed journal article:

      https://www.nature.com/articles/s41590-025-02286-5

      From the linked article:

      Antibody discovered that blocks almost all known HIV variants in neutralization assays

      An international research team led by the University of Cologne has **discovered an antibody that could advance the fight against HIV. The newly identified antibody 04_A06 proved to be particularly effective in laboratory tests. It was able to neutralize 98.5 percent of more than 300 different HIV strains, making it one of the broadest antibodies against HIV identified. In experiments with humanized mice – animals whose immune system has been modified to resemble that of humans – 04_A06 permanently reduced the HIV viral load to undetectable levels**. Most other HIV antibodies, in contrast, only achieve short-term effects in this animal model, as resistance develops quickly. The study ‘Profiling of HIV-1 elite neutralizer cohort reveals a CD4bs bNAb for HIV-1 prevention and therapy’ was published in Nature Immunology.

    2. No-Tone-6853 on

      Must be insane for some people to have witnessed HIV be a death sentence to in the near future it being an easily fixed issue. Just, WOW! Science is amazing.

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