Wissenschaftler haben eine „auffällige“ Umkehrung der Alzheimer -Krankheit bei Mäusen erreicht, indem sie die normale Funktion des Gefäßsystems des Gehirns wiederhergestellt hat – das Netzwerk von Blutgefäßen, das sie mit Sauerstoff und Nährstoffen versorgt
https://www.newsweek.com/alzheimers-disease-striking-reversal-mice-10834889
9 Kommentare
> “Our study demonstrated remarkable efficacy in achieving rapid Aβ clearance [in Alzheimer’s the main ‘waste’ protein is amyloid-β], restoring healthy function in the blood–brain barrier [known as the BBB] and leading to a striking reversal of Alzheimer’s pathology,” said study author Lorena Ruiz Perez, researcher at the Molecular Bionics group from the IBEC, in a statement.
> Instead of targeting neurons or other brain cells, the therapy restores the proper function of the BBB, the “vascular gatekeeper” that regulates the brain’s environment, according to the researchers
>“By restoring this ‘gatekeeper,’ we help the brain rebalance itself and make any other therapy work better,” Giuseppe Battaglia, Catalan Institution for Research and Advanced Studies (ICREA) research professor at IBEC, told Newsweek.
>
>“Today, no treatment reliably reverses Alzheimer’s; at best, some slow aspects of decline. Our results point to a new path: fix the barrier that keeps the brain healthy.”
[Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport | Signal Transduction and Targeted Therapy](https://www.nature.com/articles/s41392-025-02426-1)
Soooo it comes back to irrigation of the brain?
Soooo it comes back to irrigation of the brain?
Wait, How much if a reversal tho? Are we talking about the first stages of the illness or when damages are stacking up?
how remarkable. medical technology has come such a long way.
hopefully this will work well in humans; diseases like alzheimer’s are so devastating for the person and everyone around them.
Let’s just hope the promising mouse model to successful human clinical trials transition is a smooth one.
There was also a lot of excitement lately about the relationship between lithium depletion and dementia
[https://hms.harvard.edu/news/could-lithium-explain-treat-alzheimers-disease](https://hms.harvard.edu/news/could-lithium-explain-treat-alzheimers-disease)
Couldnt find the actual study, just read the article but my interpretation of this would be that there is more overlap between vascular dementia and Alzheimer’s dementia than we think. Restoring health brain microvasculature is nothing something we can actually do in humans, again because I didn’t read the study Im not sure how they did that in mice. And keeping up with a diet/lifestyle that promotes vascular health should be done regardless.
I’m not the smartest dude, nor able to understand a lot of these big words. But the big question for me personally is how did they know the mouse had Alzheimer’s? Another one is if they didn’t know it had Alzheimer’s and gave it Alzheimer’s, how do you give a mouse Alzheimer’s? Ignore my ignorance these are genuine questions.