Enzym hinter der diätinduzierten Fettleibigkeit und Diabetes kann „ausgeschaltet“ | Das Ausschalten des CaMKK2-Enzyms bei Mäusen verhinderte durch Diät induzierte Fettleibigkeit und verbesserten Stoffwechsel.

From the article: Switching off a single enzyme in immune cells protected mice from obesity, type 2 diabetes, and fatty liver disease in a [new study](https://www.sciencedirect.com/science/article/pii/S2212877825001577), offering a potential new treatment target for metabolic disorders.

The worldwide prevalence of obesity more than tripled in the nearly 50 years between 1975 and 2022, according to the World Obesity Federation. There have been countless studies on the negative effects of overweight or obesity on health. Now, a new study by researchers at Monash University, Melbourne, and Baylor College of Medicine, Texas, has identified an enzyme, CAMKK2, that, when “switched off” in immune cells, prevented diet-induced obesity, diabetes and fatty liver disease in mice.

“Obesity is linked to ongoing, low-level inflammation in key organs that control metabolism, like the liver, fat tissue and muscles, and this kind of inflammation plays a role in conditions such as insulin resistance and type 2 diabetes,” said John Scott, PhD, a senior research fellow from the Monash Institute of Pharmaceutical Sciences (MIPS) and one of the study’s corresponding authors. “It’s widely accepted that a big driver of this process is the buildup of macrophages in these organs because when the body is under stress, such as from a high-fat diet, inflammatory macrophages switch to a faster but less efficient way of making energy.”

>They found that mice without CAMKK2 in macrophages resisted high-fat-diet-induced weight and fat gain. Although they didn’t eat less food, they burned more energy. 

How were they releasing that energy, and how would it translate into humans? Because if it just gets released as heat, it’s not really suitable for us. We already have DNP which hinders ATP production and as a result releases energy as heat, which has lead to many deaths by people who abuse steroids.

So what happens to the extra energy from diet that doesn’t get stored as fat anymore? How are they burning it?