Unter Verwendung von gentechnisch veränderten Mäusen, 3D-Tumororganoiden und dem größten verfügbaren Datensatz menschlicher SCLC-Tumoren (bei 944 Proben) verfolgen die Forscher Lungenkrebs mit Kleinzell-Lungenkrebs zurück zu basalen Stammzellen, die Hinweise darauf bieten, wie die Krankheit beginnt und potenzielle Frühinterventionstherapien informiert.
https://corporate.dukehealth.org/news/basal-stem-cells-identified-origin-small-cell-lung-cancer-lab-models
2 Kommentare
Link to paper: [Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer
](https://www.nature.com/articles/s41586-025-09503-z)
Wow, this is fascinating! Tracing small-cell lung cancer back to basal stem cells could be a huge step toward **earlier detection and targeted therapies**. Using 3D tumor organoids alongside such a large dataset really strengthens the findings, too.
I wonder how soon these insights could translate into **clinical interventions or screening protocols**. It’s exciting to see research combining genetics, organoids, and big data to tackle something as aggressive as SCLC.
This kind of work really shows the potential of combining lab models with human data to accelerate cancer research.