Eine neue tägliche orale Pille namens ORFORGLiPRON, die sich auf die gleichen GLP-1-Rezeptoren wie Gewichtsverlustinjektionen abzielt, kann Menschen helfen, ihr Körpergewicht um bis zu einem fünften zu verringern. In einem Versuch mit 3.127 Erwachsenen verlor eine von fünf Personen, die 72 Wochen lang die einst tägige Tablette einnahm, 20% oder mehr seines Körpergewichts.

I’ve linked to the news release in the post above. In this comment, for those interested, here’s the link to the peer reviewed journal article:

https://www.nejm.org/doi/full/10.1056/NEJMoa2511774

From the linked article:

**A daily pill for weight loss can help people reduce their body weight by as much as a fifth**, according to a trial that could pave the way for millions more people to shed pounds.

**The drug, called orforglipron, is manufactured by Eli Lilly and targets the same GLP-1 receptors as weight loss injections such as Mounjaro and Wegovy. In a trial of 3,127 adults, one in five people who took the once-a-day tablet for 72 weeks lost 20% or more of their body weight**.

Weight loss jabs have been transformative but pill versions are seen as a holy grail because they are easier to store, distribute and administer and are also expected to be cheaper, offering fresh hope for the millions of people trying to lose weight.

Orforglipron is a GLP-1 agonist, a type of medication that helps lower blood sugar levels, slows the digestion of food and can reduce appetite.

The weight loss seen among people taking the tablet is not as stark as that among patients taking tirzepatide (Mounjaro), which is also made by Eli Lilly, but experts believe the tablet will be more accessible and convenient compared with injections.

An overweight friend tried an oral GLP-1 inhibitor but it stopped working after only losing 15lbs. Not sure how much they exercised or changed their diet but I’m curious about any other factors that can limit the effectiveness of GLP-1 inhibitors.