Wissenschaftler konstruierte E. coli -Bakterien, um PDCA, ein biologisch abbaubares Material mit physikalischen Eigenschaften zu produzieren, auf beispiellose Ebene übereinstimmen oder übertreffen

> Kobe University bioengineer TANAKA Tsutomu says: “Most biomass-based production strategies focus on molecules consisting of carbon, oxygen and hydrogen. However, there are highly promising compounds for high-performance plastics that include other elements such as nitrogen, but there are no efficient bioproduction strategies. And purely chemical reactions inevitably generate unwanted byproducts.” PDCA, which stands for pyridinedicarboxylic acid, is such a candidate. It is biodegradable, and materials incorporating this show physical properties comparable to or even surpassing those of PET, which is widely used in containers and textiles. “Our group approached the challenge from a new angle: We aimed to harness cellular metabolism to assimilate nitrogen and build the compound from start to finish,” says Tanak

> The group, however, did have some stubborn problems to solve along the way. The most stubborn of these came when they discovered a bottleneck where one of the enzymes they had introduced produced the highly reactive compound hydrogen peroxide, H2O2. The compound then attacked the enzyme that produced it, thereby deactivating it. “Through refining the culture conditions, in particular by adding a compound that can scavenge H2O2, we could finally overcome the issue, although this addition may present new economic and logistical challenges for large-scale production,” says Tanaka

[Biosynthesis of 2,5-pyridinedicarboxylate from glucose via p-aminobenzoic acid in Escherichia coli – ScienceDirect](https://www.sciencedirect.com/science/article/pii/S1096717625001302?via%3Dihub)