Verwenden von Bakterien zum Einschleichen von Viren in Tumoren: Wissenschaftler zeigen, wie ihr neues System ein onkolytisches Virus in einem Tumorsuch -Bakterium verbirgt, schlägt es über das Immunsystem vorbei und löst es in Krebstumoren aus, während das Virus in Mausmodellen validiert wird.

Using bacteria to sneak viruses into tumors

The bioengineered platform enables a cancer-killing virus to evade the patient’s immune system — and prevents it from spreading throughout the body.

Researchers at Columbia Engineering have built a cancer therapy that makes bacteria and viruses work as a team. In a study published today in Nature Biomedical Engineering, the Synthetic Biological Systems Lab shows how their system hides a virus inside a tumor-seeking bacterium, smuggles it past the immune system, and unleashes it inside cancerous tumors.

The researchers believe that this technology — validated in mice — represents the first example of directly engineered cooperation between bacteria and cancer-targeting viruses.

For those interested, here’s the link to the peer reviewed journal article:

https://www.nature.com/articles/s41551-025-01476-8