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    1. I’ve linked to the press release in the post above. In this comment, for those interested, here’s the link to the peer reviewed journal article:

      https://link.springer.com/article/10.1007/s11357-025-01786-4

      From the linked article:

      UC Irvine researchers find combination of natural compounds for brain cleaning

      Treatment removes harmful protein buildup associated with Alzheimer’s disease

      **A form of vitamin B3 and an antioxidant found in green tea help brain cells eliminate damaged bits and boost energy levels.**

      **Compounds reduce protein plaques linked to Alzheimer’s disease in aging brains.**

      The National Institutes of Health and the UC Irvine Foundation funded the project.

      Researchers at the University of California, Irvine have identified a promising nonpharmaceutical treatment that rejuvenates aging brain cells and clears away the buildup of harmful proteins associated with Alzheimer’s disease.

      In a paper published recently in the journal GeroScience, the UC Irvine team reports that a combination of naturally occurring compounds – nicotinamide (a form of vitamin B3) and epigallocatechin gallate (a green tea antioxidant) – can reinstate levels of guanosine triphosphate, an essential energy molecule in brain cells. In tests on neurons in a dish, the treatment reversed age-related cellular deficits and improved the brain cells’ ability to clear damaging amyloid protein aggregates, an Alzheimer’s hallmark.

    2. High dose vitamin B3 is also supposed to reduce the incidence of basal cell skin cancers

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