CRISPR, mit dem zusätzliche Chromosomen beim Down -Syndrom entfernt und menschliche Zellfunktion wiederhergestellt werden. Japanische Wissenschaftler entdeckten, dass das Entfernen der nicht benötigten Kopie mithilfe von CRISPR-Genen-Gene-Normalisierte in Laborgewachsenen menschliche Zellen entfernt wurde.
https://www.earth.com/news/crispr-used-to-remove-extra-chromosomes-in-down-syndrome-and-restore-cell-function/
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CRISPR used to remove extra chromosomes in Down syndrome and restore cell function
Ryotaro Hashizume and colleagues from Mie University in Japan report that it is possible to cut away the surplus chromosome in affected cells, which appears to bring their behavior closer to typical function.
CRISPR-Cas9 is a versatile gene-editing system that relies on an enzyme to recognize specific DNA sequences. Once the enzyme locates a matching site, it snips through the DNA strands.
Scientists carefully design CRISPR guides to target only the unwanted chromosome. This trick is called allele-specific editing, and it helps steer the cutting enzyme to the right spot.
Their group discovered that removing the unneeded copy often normalized gene expression in laboratory-grown cells.
The treated cells reverted to typical patterns of protein manufacturing. They also showed better survival rates in certain tests, indicating that the excess genetic burden was successfully relieved.
The researchers didn’t just test their approach on lab-grown stem cells. They also applied it to skin fibroblasts, which are more mature, non-stem cells taken from people with Down syndrome.
Here’s the link to the peer reviewed journal article:
https://academic.oup.com/pnasnexus/article/4/2/pgaf022/8016019
inb4 the „BUT AT WHAT COST?!??“ people start freaking out about eugenics and what the terrible loss of Down Syndrome will do to humanity’s collective heritage
I wonder if this can be applied to other conditions like Fragile X
Since this is way above my brain level could someone with more brain cells explain?
CRISPR modifies the chromosomes, get that. Would it not have to be at a very early stage in the embryos development though, as in before we can detect it at 10 weeks or so? I’m assuming they’re not saying to Steve, the 23 year Down syndrome guy, get over here you’re in for a wild ride…?
CRISPR used to remove extra chromosomes. It still does but it used to too.
Yeah, while I’ll be the first to point out the crossover and causation with intelligence, creativity, less intense autism and ADHD, and how fully removing those from society would be a really bad idea.
Things like Down syndrome, schizophrenia, bipolar and so on have no noted payoff or role for the species, or at least anywhere near as obvious.