Femur Knochendichte Verlust bei Mäusen an Bord der ISS schenkt Licht auf die Raumfahrtprobleme

I have a question.

How would the rapid degradation of the body we see in space travel/occupance effect someone who just permanently lived in space? Like if we built a station meant for long-term stays and sent astronauts up to live there and run it, would the lost bone density and muscle atrophy actually be that much of an issue if they’re constantly in zero-G? Is it degradation or is it the body acclimating to living in space?