Neue Forschungsergebnisse ergaben, dass Menschen, die Semaglutid zur Gewichtsreduktion einnahmen, nach 60-wöchiger Einnahme des Medikaments weiterhin deutlich weniger Kalorien zu sich nahmen, was erklärt, wie das Medikament sowohl den anfänglichen Gewichtsverlust als auch die langfristige Gewichtserhaltung unterstützt
https://www.pennmedicine.org/news/semaglutide-still-has-benefits-after-one-year
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People taking semaglutide for weight loss continued to consume significantly fewer calories after 60 weeks on the medication, helping explain how the medication supports both initial weight loss and long-term weight maintenance. The study, published in the American Journal of Clinical Nutrition and led by investigators from Penn’s Center for Weight and Eating Disorders and Penn Metabolic Medicine, is among the first to examine the long-term effects of semaglutide on eating behavior beyond the initial months of treatment.
Researchers found that while some of the medication’s early reduction of hunger and food-related thoughts became less pronounced over time, participants continued to eat substantially fewer calories than those receiving placebo after more than a year of treatment.
„Many patients worry that their medication has stopped working if they notice some return of hunger after the first several months,“ said Jena S. Tronieri, PhD, lead author of the study and senior research investigator in the Center for Weight and Eating Disorders at Penn Medicine. „Our findings show that even when people feel some of those sensations returning, semaglutide continues to help them eat less. That sustained reduction in calorie intake appears to be a key reason why weight loss is maintained over time.“
https://www.sciencedirect.com/science/article/pii/S0002916526002121?via%3Dihub
This is GLP. Isn’t this the entire point?
I remember like 10 years ago people were talking about how they already have medications that can increase your expenditure for calorie burning, but those have a lot of risks with them, especially with the heart
So they were looking at things that could truly curb one’s hunger and they found this I thought
So this is not exactly a shocking revelation
I would assume less calories
I’ve been on Ozempic for about a year, and I feel like the impact starts to wear off. Some of the food noise comes back. I’ve upped my dose to see if it kicks starts the weight loss/food noise reduction again but may see about switching to Mounjaro see if there’s a difference. Was at 260 with type 2, now at 225 all blood work is great but I get cravings again especially sugar.
I’m confused. So it says if they take the lifetime drug for 60 weeks it continues working? We didn’t know that? I thought th issues were we have zero true longterm studies on weight loss without diabetes
This seems stupid. They measured how much lunch they all ate after 20, 40, 60 weeks and compared to people who were on a placebo. But like, I don’t eat a lot now. My 2 gal friends eat double what I eat every day. How do you baseline that?
This is anecdotal, but I took Semaglutide from July 2023-December 2024. Before Semaglutide, I was drinking almost an entire bottle of wine every night. Not something I’m proud of, but that habit led me to gaining a lot of weight and put my A1C as prediabetic. Semaglutide destroyed my craving for alcohol and sweets and to this day these cravings have not returned. These days, I probably have one drink a week when my husband and I go out to dinner and I almost never eat anything sweet. It just doesn’t taste good to me. I do have more food noise and hunger, but I feel I make pretty good food choices overall. I have maintained all the weight I lost with Semaglutide and I’ve even lost an additional 10 pounds since taking up pickleball in August of 2025.