Beliebte GLP-1-Medikamente wie Semaglutid helfen möglicherweise weit mehr als nur bei Diabetes und Gewichtsverlust – sie könnten auch die Sucht selbst bekämpfen. Untersuchungen ergaben, dass die Risiken bei allen untersuchten Hauptsubstanzen geringer waren, darunter Alkohol (18 %), Cannabis (14 %), Kokain (20 %), Nikotin (20 %) und Opioide (25 %).
27 Kommentare
Researchers at Washington University School of Medicine in St. Louis show in a new study that GLP-1 medications may be effective at treating and preventing substance use disorders across all major addictive substances studied, suggesting these drugs target a common biological pathway underlying addiction.
From their beginnings as a treatment for type 2 diabetes, GLP-1 receptor agonists such as the semaglutide drugs Ozempic and Wegovy and the tirzepatide drugs Mounjaro and Zepbound have seen an explosion in use, most popularly for weight loss. Patients have reported decreased interest in alcohol and nicotine when taking GLP-1s, and observational studies have shown an association between treatment with GLP-1 medication and lower risk of alcohol and cannabis use disorders, opioid overdose, and alcohol-related hospitalization. But these studies examined substances one at a time. No study has asked the broader question: do GLP-1s work against substance use disorders across the board, and can they reduce the serious harms of addiction, including overdose and drug-related death?
In an analysis of more than 600,000 U.S. veterans with type 2 diabetes, the WashU Medicine team found GLP-1s are tied to a reduced risk of developing substance use disorders across all major addictive substances and to a reduced risk of severe harm, including overdose and death, in people who already have such disorders.
In an analysis of more than 600,000 U.S. veterans with type 2 diabetes, the WashU Medicine team found GLP-1s are tied to a reduced risk of developing substance use disorders across all major addictive substances and to a reduced risk of severe harm, including overdose and death, in people who already have such disorders.
The results appear March 4 in The BMJ.
“In addiction medicine, a lot of treatments target just one thing — for example, a nicotine patch helps with smoking, but not alcohol — but there is no medication that works across addictive substances, let alone all of them,”
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2026.1766770/full?asam.org
Anecdotal but the Wegovy pill caused me to break a lifelong caffeine addiction – can’t even finish a cup of coffee anymore or I forget about it.
What is the mechanism of action that causes this decrease in craving? Is it decreasing psychological or physical craving?
Loss of interest and motivation as well right?
So obese people are addicted to food and the drug helps their addiction?
Hopefully not by negatively effecting dopamine
Cause that could cause anhedonia
Anecdotal, but strangely enough I had been trying to quit nicotine for years, and about a month after I started tirz I finally kicked the damn habit…
For what it’s worth, my step dad told me his desire to drink alcohol went off a cliff after he started Mounjaro.
I’m an alcoholic on glp, yes it also helps in this regard, I have years of sobriety but it’s even easier now
There’s no way in all of creation changing your brain that much that fast is good. I can’t see how this ends well.
What about porn addiction? If it works on that by inhibiting the urge would it also decrease sex drive too?
I have a relative and a former co-worker who both quit smoking after having been Mounjaro for a few months. I don’t know if the co-worker is still not smoking, but my relative has never went back. She said it was like she never smoked and just had zero interest.
2.5 months on a glp-1 and I went from like 12-18 drinks a week to maybe 2 and I usually can’t finish them. The main downside I’ve noticed is I often forget to even drink water and end up accidentally dehydrated.
Yeah it kinda sucks, I really don’t enjoy alcohol the same way since I’m on semaglutide.
I can’t wait for more studies on semaglutide and other similar medecines. It apparently also helps with PCOS and inflammation.
It’s anhedonia from starvation.
This is wild. I was literally talking to my wife about how I thought this was the case today since it helped her stop drinking so much. There’s definitely something going on with dopamine, or reward systems, or something in there.
If you are spending 200+ a month on an injection I imagine it cuts into your weed and drinking money
Sounds like general desires and rewards are curbed.
I’d be curious how this affects people’s enjoyment of positive activities (like working out or hobbies).
For sure agree here from my own experience, my interest in both coffee (5 or 6 cups a day in the past) and alcohol (maybe 10 or so beers/drinks per month, granted was not a significant amount) has diminished to near 0 over the last year on semaglutide. The desire for both is simply gone.
Industrial Sugar is missing in this List?
Currently in Retatrutide and have no desire to Drink alcohol. These GLP-1’s are life changing for many people.
Absolutely believe that, my binge eating used to mean I could not pull away from food sometimes. I never had the reflex where my brain was like „that’s enough for right now.“ It didn’t exist. I am living a whole other life now, the food noise has COMPLETELY fallen off and I can eat like a normal person now. I cried a few times that first month with the weight that was removed from my shoulders.
Yupp they kicked my coke cravings by a lot. Clean 3 weeks down from 4-5 days a week stuff is amazing.
Don’t need all my vices when I’m shredded and absolutely plowing women like they were an english country side
This happened when I was on Zepbound. I didn’t just lose weight, I didn’t *want* anything. Honestly, I miss it.
That could crash the American economy, as American life is just a collection of addictions.