Wow, was können diese GLP-1-Medikamente nicht? Macht nicht nur schlank, sondern steigert auch die Herz-Kreislauf-Gesundheit, den Blutdruck und entzündungsbedingte Krankheiten und verbessert offenbar auch die Aussichten für einige Krebsarten.
Da sie nun in Gebieten auf der ganzen Welt (Indien, Brasilien und Kanada im Jahr 2026) in ihr generisches Zeitalter eintreten, sollten wir in diesen Ländern dramatische gesundheitliche Verbesserungen beobachten.
Beliebtes GLP-1-Medikament kann laut Analyse die biologische Alterung verlangsamen
Popular GLP-1 drug may slow down biological aging, analysis indicates.
byu/lughnasadh inFuturology
30 Kommentare
From the article: “Now, a new study provides the first randomized, placebo-controlled clinical evidence that semaglutide, a widely used GLP-1 drug, slows down the accumulation of biological aging markers in the DNA of adults with HIV.”
Bit of a qualifier there.
These are lifetime drugs. Once you start, going off them usually means losing all benefits (weight gain, A1c changes, etc.).
Isn’t it just that fasting slows down biological aging?
I suspect there are downsides to these GLP-1 drugs that are yet to be discovered. I hope not of course! Just got a feeling. It seems too good to be true.
I find these drugs to be highly suspiciously too good at everything. What is the drawback?
I mean doesn’t fasting do this? Don’t these drugs make you not want to eat? Is this fasting or the drug causing this.
I think it’s more like, our over eating was causing us to get fat, have diabetes, inflammation and age prematurely
We have over thousands of years not had ready access to foods so evolutionary theory would say that those people who maximised their calorie intake and fat absorption – when their is a period of excess – have an inherent advantage over ’leaner’ metabolism types.
Food, relatively speaking from an evolutionary perspective, became abundant yesterday and we’ve not had time to adapt. Ultra processed foods exasperated this underlying mechanism and for the western world diet has led to where we are today.
The GLP-1 drug mentioned in the article isn’t some new discovery. It’s semaglutide, better known under the brand name **Ozempic**, the drug that became famous for its effects on type 2 diabetes and weight loss.
The benefits for weight loss, diabetes, heart health, blood pressure, and inflammation are fairly well established by now.
But the „slows biological aging“ headline is getting ahead of the evidence. One thing worth noting is that **the study compared HIV patients receiving semaglutide with HIV patients receiving a placebo.** I***t did not test semaglutide against placebo in a healthy population.*** So the results show a potential benefit in that specific HIV-associated group, but they don’t automatically demonstrate the same anti-ageing effect in the general population.
I don’t know if these drugs slow down ageing so much as they reduce inflammation, and THAT shortens your life in a lot of ways. Correlation is not causation.
Haha no wonder my insurance doesn’t want to cover it for my fat ass!!
At this point, GLP-1 drugs are starting to sound like the „vitamin D“ of the 2020s—every few months there’s a new study linking them to another major health benefit. The big question is: which effects are actually direct, and which are just a consequence of people becoming healthier overall?
Yeah this all just sounds like the effects of losing weight. In fact, basically everything attributed to these drugs, costs and benefits, sounds exactly like the effects of losing weight.
It’s starting to feel more and more like these are ads more than studies. Next there will be one that’s just „Study suggests GLP-1 drugs might make your dick bigger!“
I’ve been using tirzepatide (Zepbound “generic”-a lot cheaper and just as good) and what I’ve come to believe is that our diet does far more harm to our whole body than previously thought. I think the fact that the drugs fix your insulin resistance and metabolism while also fixing your hunger signals and all the other side-quest fixes like less aches and pains, more energy, menopausal side effects gone, addictions gone, and now potentially preventing cancer etc. means (to me) that we really need to do something about our food industry. It is truly a miracle drug. Never felt better in my life.
You did read the part where the people in the single study have HIV, right?
Handsome quarterback also valedictorian, volunteers at children’s hospital
Shocker: being fat is bad for you. Who’d have guessed?
I was a hater, but if this is the fountain of youth
Give me
I’m already slim af. I don’t need it for weight loss
I’m already on a GLP1 medication, all I need now is to get HIV 👀
It makes sense when you think about it. There have been many studies that link a lower metabolic rate to increased life expectancy, with intermittent fasting as the method to get there. Just like if you only drive your car 10,000 miles in a year, it will last longer than if you drive it 20,000 miles in a year. GLP-1 drugs enforce intermittent fasting by making you forget about food for the most part; you can obviously go too far with that, but used sensibly it could be a big benefit.
I’ve had lupus (SLE) for years and was historically very fit. The disease comes with frequent loss of energy (poor ATP production), joint pain, and a host of other issues. The imposed limits on workouts as well as side effects from meds caused me to gain weight. I went on semaglutide two years ago, dropped 60 pounds in 7 months, and have stayed at that weight since. Most importantly, it’s reduced my inflammation and allows me to do body weight exercise most days now. I still battle lupus flairs fairly often but I am now able to keep my body much better prepared to get through them and on with life relatively quickly. GLP-1 agonists have proven to be a real differentiator in my health and I am thankful they exist.
I need a GLP drug that fixes my horrible eyesight, restores my hair and heals by back.
Theyre also really effective at treating alcoholism, smoking and other addictions.
Only significant side effects I’ve heard of are fatigue.
Those drugs should be cheap and OTC, If I was president I would buy the patents by a fraction of what the Iran War is costing and start producing generics, imagine the gains in productivity and less health issues. Not to mention that people would spend less money on food and gambling.
Born too late to explore the world, born too soon to get affordable GLP-1.
I was on Zepbound for 3 months and the only thing I got out of it was relentless nausea and unshakeable fatigue. My body continues to find new and fascinating ways to fuck me over.
Well I don’t know about aging but since others are reporting their side effects or non, here’s mine. I’m about to turn 80, on Mounjaro about a year now, have „only“ lost about 45lbs eating c.1450 calories a day. Side effects: chronic constipation, bedtime gerd about twice a week, daily hypersalivation just short of drooling, and sulfur burps around 2 days a week.
Gosh, it’s almost like they’re the miracle drugs that we wanted for so long and worked towards for decades. However, we better punch down on them cause people might get healthier the „wrong“ way and they might get nauseous and aren’t perfect.
Monjero helped me lose nearly 20kg, like overnight. It felt like fucking magic. From 105 to 83kg in a mere 3 months. Effortlessly.
I decided to stay on it. But I can’t… The side effects are horrendous. Textbook torturous fatigue. Once I hit 83kg (which I plateaued), I should have come off it. But I already pre-bought another six months‘ supply. Out of pocket. So not cheap. I have 4 months left, but I am stopped.
I am talking like I sleep 10 hours at night and still can’t wake up. ZERO energy to do anything. I can nap almost any time of the day. It has become so difficult to do my job.
I still think its a mirical drug. But there is no way I can be on it long term. So all these positive long-term side effects are not worth the insane fatigue.