Jedes Organ bringt seinen Nerven bei, was sie werden sollen: Das „zweite Gehirn“ des Darms hat Geschwister im Herzen, in der Lunge und in der Bauchspeicheldrüse, und jedes Organ baut sein eigenes kleines Nervensystem von Grund auf auf. Sie tun dies, indem sie lokale Anweisungen erteilen, anstatt sie vom Gehirn zu empfangen.

    https://dailyneuron.com/organ-intrinsic-nervous-systems/

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    1. undulating-beans on

      The headline is doing what science headlines often do: taking a real underlying finding and presenting it in a way that sounds rather more dramatic than the underlying science actually is.

      The “gut’s second brain” refers to the enteric nervous system, which is a genuine and remarkably complex network of neurons embedded throughout the gastrointestinal tract. It contains hundreds of millions of neurons and can coordinate a great deal of digestive function locally, including motility, secretion, and reflex responses, without needing every detail to be routed through the brain in real time. That is why it gets nicknamed the “second brain,” although that is a journalistic label rather than a strict anatomical one.

      The suggestion that the heart, lungs, and pancreas have “siblings” of this system is partly true, but the wording is loose. Many organs do have intrinsic neural circuitry or local autonomic ganglia that allow some degree of local processing and reflex control. The heart, for example, has an intrinsic cardiac nervous system, sometimes informally called the “little brain of the heart.” The lungs have extensive autonomic innervation and local reflex pathways. The pancreas also has neural regulation affecting secretion, blood flow, and communication with the gut and central nervous system. But these are not miniature independent brains sitting in each organ making autonomous decisions in the way the headline implies.

      The “builds its own nervous system from scratch” claim is likely referring to developmental biology research showing that organs are not passive recipients of innervation. During embryonic development, tissues release local molecular signals such as growth factors, chemokines, extracellular matrix cues, and adhesion molecules that help guide nerve growth, neuronal migration, differentiation, and synapse formation. In other words, the developing organ helps shape how its innervation forms. That is scientifically interesting and absolutely real.

      What is misleading is the phrase “from scratch,” because neurons do not spontaneously arise because an organ independently decides to invent a nervous system. The cells involved come from established developmental lineages, often neural crest-derived populations, following genetic developmental programmes and tissue signalling interactions.

      The claim that organs do this “rather than receiving instructions from the brain” is probably the weakest part of the framing. The brain is not normally acting as some central construction foreman directing embryonic nerve wiring one connection at a time. Development is distributed and heavily dependent on local signalling, gene expression, developmental gradients, and reciprocal interactions between tissues. So the contrast being presented is somewhat artificial.

      The accurate version is much less dramatic: organs help direct the development and local organisation of their own neural circuitry through tissue-derived signalling cues. That is fascinating biology, but it is not evidence that your pancreas has developed opinions!

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