LSD-Mikrodosierung ist mit akuten Stimmungsverbesserungen bei Erwachsenen mit Depressionen verbunden. In einer kleinen Pilotstudie berichteten Teilnehmer, die niedrige, präzise Dosen einnahmen, dass sie sich an den Tagen, an denen sie das Medikament einnahmen, energiegeladener, kreativer und verbundener fühlten.

LSD microdosing linked to acute mood improvements in adults with depression

Taking tiny, frequent amounts of the psychedelic drug lysergic acid diethylamide (LSD) might temporarily elevate mood for people diagnosed with major depressive disorder. In a small pilot study, participants taking low, precise doses reported feeling more energetic, creative, and connected on days they took the drug. The research was published in the journal Progress in Neuropsychopharmacology & Biological Psychiatry.

Classic psychedelic compounds such as LSD are known for inducing profound changes in perception at high amounts. For decades, strict legal restrictions largely halted clinical research on these substances. Recently, scientific interest has renewed, and a practice called microdosing has gained popularity globally.

This practice involves taking very small amounts of a psychedelic substance. The amount is high enough to potentially alter brain chemistry but low enough to avoid causing hallucinations or severe cognitive disruptions. Many individuals practice microdosing on their own to self-medicate for mental health conditions, particularly depression.

To test this approach, the research team enrolled nineteen adults who all met diagnostic criteria for major depression. They underwent an eight-week treatment regimen. The first session took place in a clinical laboratory. Participants were given a precise, eight-microgram dose of liquid LSD in a sublingual format. Sublingual administration involves holding the liquid under the tongue for about thirty seconds before swallowing.

Looking at the data across the eight weeks, daily mood improved in specific patterns. On the specific days they consumed the microdose, participants logged higher levels of creativity, energy, and social connectedness compared to the days immediately following the dose. On the first and second days after taking the drug, participants reported feeling happier. In addition, irritability scores dropped two days after consuming the dose.

These acute improvements in mood could theoretically counter some of the core symptoms of major depressive disorder. A common feature of depression is anhedonia, which is an inability to feel pleasure or find motivation to engage in social activities. If a patient feels a temporary surge in creative energy and social connection, they might be more likely to participate in positive social behaviors. Engaging in rewarding activities can create a positive feedback loop that helps lift a depressed mood over time.

https://www.sciencedirect.com/science/article/pii/S0278584626000412

With LSD being found in a fungus recently it makes me wonder how much of our cognitive advances are related to diet.

I’m suspicious that the last three posts on the sub are all ‚abusable substance actually makes brain work better‘. Two are by the same person.

Even on extremely high doses, I had nothing like I experienced on SSRI. It almost killed me. I really thought I needed one because of my positive experience. I can’t believe what I had. It was the most insane and terrifying experience of my life. Let nature make the medicines.